| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| alaS | yqgF | ICMP_556 | ICMP_562 | alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain; Belongs to the class-II aminoacyl-tRNA synthetase family. | Holliday junction resolvase-like protein; Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA; Belongs to the YqgF HJR family. | 0.538 |
| gshB | metK | ICMP_560 | ICMP_558 | Glutathione synthetase; Belongs to the prokaryotic GSH synthase family. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.440 |
| gshB | yggS | ICMP_560 | ICMP_563 | Glutathione synthetase; Belongs to the prokaryotic GSH synthase family. | Predicted enzyme; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis. | 0.572 |
| gshB | yqgE | ICMP_560 | ICMP_561 | Glutathione synthetase; Belongs to the prokaryotic GSH synthase family. | Hypothetical protein; Belongs to the UPF0301 (AlgH) family. | 0.733 |
| gshB | yqgF | ICMP_560 | ICMP_562 | Glutathione synthetase; Belongs to the prokaryotic GSH synthase family. | Holliday junction resolvase-like protein; Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA; Belongs to the YqgF HJR family. | 0.798 |
| metK | gshB | ICMP_558 | ICMP_560 | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | Glutathione synthetase; Belongs to the prokaryotic GSH synthase family. | 0.440 |
| metK | yqgE | ICMP_558 | ICMP_561 | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | Hypothetical protein; Belongs to the UPF0301 (AlgH) family. | 0.413 |
| metK | yqgF | ICMP_558 | ICMP_562 | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | Holliday junction resolvase-like protein; Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA; Belongs to the YqgF HJR family. | 0.407 |
| miaA | yqgF | ICMP_177 | ICMP_562 | tRNA delta(2)-isopentenylpyrophosphate transferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. | Holliday junction resolvase-like protein; Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA; Belongs to the YqgF HJR family. | 0.475 |
| pyrB | yqgE | ICMP_301 | ICMP_561 | Aspartate carbamoyltransferase catalytic subunit; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | Hypothetical protein; Belongs to the UPF0301 (AlgH) family. | 0.407 |
| pyrB | yqgF | ICMP_301 | ICMP_562 | Aspartate carbamoyltransferase catalytic subunit; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | Holliday junction resolvase-like protein; Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA; Belongs to the YqgF HJR family. | 0.432 |
| yggS | gshB | ICMP_563 | ICMP_560 | Predicted enzyme; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis. | Glutathione synthetase; Belongs to the prokaryotic GSH synthase family. | 0.572 |
| yggS | yqgE | ICMP_563 | ICMP_561 | Predicted enzyme; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis. | Hypothetical protein; Belongs to the UPF0301 (AlgH) family. | 0.630 |
| yggS | yqgF | ICMP_563 | ICMP_562 | Predicted enzyme; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis. | Holliday junction resolvase-like protein; Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA; Belongs to the YqgF HJR family. | 0.632 |
| yqgE | gshB | ICMP_561 | ICMP_560 | Hypothetical protein; Belongs to the UPF0301 (AlgH) family. | Glutathione synthetase; Belongs to the prokaryotic GSH synthase family. | 0.733 |
| yqgE | metK | ICMP_561 | ICMP_558 | Hypothetical protein; Belongs to the UPF0301 (AlgH) family. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.413 |
| yqgE | pyrB | ICMP_561 | ICMP_301 | Hypothetical protein; Belongs to the UPF0301 (AlgH) family. | Aspartate carbamoyltransferase catalytic subunit; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | 0.407 |
| yqgE | yggS | ICMP_561 | ICMP_563 | Hypothetical protein; Belongs to the UPF0301 (AlgH) family. | Predicted enzyme; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis. | 0.630 |
| yqgE | yqgF | ICMP_561 | ICMP_562 | Hypothetical protein; Belongs to the UPF0301 (AlgH) family. | Holliday junction resolvase-like protein; Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA; Belongs to the YqgF HJR family. | 0.944 |
| yqgF | alaS | ICMP_562 | ICMP_556 | Holliday junction resolvase-like protein; Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA; Belongs to the YqgF HJR family. | alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain; Belongs to the class-II aminoacyl-tRNA synthetase family. | 0.538 |