KLU65674.1 protein (Desulfosporosinus acididurans)

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Experiments

Co-purification, co-crystallization, Yeast2Hybrid, Genetic Interactions, etc ... as imported from primary sources.

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Cooccurrence

Gene families whose occurrence patterns across genomes show similarities.

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Databases

Known metabolic pathways, protein complexes, signal transduction pathways, etc ... from curated databases.

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Fusion

Genes that are sometimes fused into single open reading frames.

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Textmining

Automated, unsupervised textmining - searching for proteins that are frequently mentioned together.

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Coexpression

Proteins whose genes are observed to be correlated in expression, across a large number of experiments.

STRING allows inspection of the interaction evidence for any given network. Choose any of the viewers above (disabled if not applicable in your network).

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

KLU65674.1

Hypothetical protein. (262 aa)

Predicted Functional Partners:

KLU65673.1

Hypothetical protein.

0.581

KLU65675.1

Hypothetical protein.

0.538

Your Current Organism:

Desulfosporosinus acididurans

NCBI taxonomy Id: 476652
Other names: D. acididurans, DSM 27692, Desulfosporosinus acididurans Sanchez-Andrea et al. 2015, Desulfosporosinus sp. D, Desulfosporosinus sp. E, Desulfosporosinus sp. M1, JCM 19471, strain M1

Basic Settings

Network type:

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( the edges indicate both functional and physical protein associations )

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( the edges indicate that the proteins are part of a physical complex )

meaning of network edges:

evidence

( line color indicates the type of interaction evidence )

confidence

( line thickness indicates the strength of data support )

active interaction sources:

Textmining

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Advanced Settings

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TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KLU65673.1	KLU65674.1	DEAC_c23030	DEAC_c23040	Hypothetical protein.	Hypothetical protein.	0.581
KLU65673.1	KLU65675.1	DEAC_c23030	DEAC_c23050	Hypothetical protein.	Hypothetical protein.	0.417
KLU65674.1	KLU65673.1	DEAC_c23040	DEAC_c23030	Hypothetical protein.	Hypothetical protein.	0.581
KLU65674.1	KLU65675.1	DEAC_c23040	DEAC_c23050	Hypothetical protein.	Hypothetical protein.	0.538
KLU65675.1	KLU65673.1	DEAC_c23050	DEAC_c23030	Hypothetical protein.	Hypothetical protein.	0.417
KLU65675.1	KLU65674.1	DEAC_c23050	DEAC_c23040	Hypothetical protein.	Hypothetical protein.	0.538

[ The below analysis is limited to the network nodes included in the specified statistical background ]

Network Stats

number of nodes:

number of edges:

average node degree:

3.27

avg. local clustering coefficient:

0.871

expected number of edges:

PPI enrichment p-value:

0.0809

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:576

Mixed, incl. Metallo-beta-lactamase, and Protein of unknown function DUF3800

3 of 7

1.72

1.65

0.0020

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