KLU64021.1 protein (Desulfosporosinus acididurans)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

KLU64021.1

Phage head-tail joining protein. (116 aa)

Predicted Functional Partners:

KLU64022.1

0.990

KLU64025.1

0.880

KLU64027.1

0.872

KLU64018.1

0.861

xkdM_2

0.826

KLU64014.1

0.808

KLU64020.1

0.782

KLU65720.1

0.779

KLU64019.1

0.773

KLU65718.1

0.758

Your Current Organism:

Desulfosporosinus acididurans

NCBI taxonomy Id: 476652
Other names: D. acididurans, DSM 27692, Desulfosporosinus acididurans Sanchez-Andrea et al. 2015, Desulfosporosinus sp. D, Desulfosporosinus sp. E, Desulfosporosinus sp. M1, JCM 19471, strain M1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KLU64014.1	KLU64018.1	DEAC_c40080	DEAC_c40120	Phage-related minor tail protein.	Phage tail sheath protein.	0.714
KLU64014.1	KLU64019.1	DEAC_c40080	DEAC_c40130	Phage-related minor tail protein.	Hypothetical protein.	0.618
KLU64014.1	KLU64020.1	DEAC_c40080	DEAC_c40140	Phage-related minor tail protein.	Hypothetical protein.	0.718
KLU64014.1	KLU64021.1	DEAC_c40080	DEAC_c40150	Phage-related minor tail protein.	Phage head-tail joining protein.	0.808
KLU64014.1	KLU64022.1	DEAC_c40080	DEAC_c40160	Phage-related minor tail protein.	Phage gp6-like head-tail connector protein.	0.974
KLU64014.1	KLU64025.1	DEAC_c40080	DEAC_c40190	Phage-related minor tail protein.	Phage capsid family protein.	0.754
KLU64014.1	KLU64027.1	DEAC_c40080	DEAC_c40210	Phage-related minor tail protein.	Phage portal protein.	0.790
KLU64014.1	KLU65718.1	DEAC_c40080	DEAC_c23480	Phage-related minor tail protein.	Phage portal protein.	0.686
KLU64014.1	KLU65720.1	DEAC_c40080	DEAC_c23500	Phage-related minor tail protein.	Phage capsid family protein.	0.634
KLU64014.1	xkdM_2	DEAC_c40080	DEAC_c40110	Phage-related minor tail protein.	Phage-like element PBSX protein XkdM.	0.724
KLU64018.1	KLU64014.1	DEAC_c40120	DEAC_c40080	Phage tail sheath protein.	Phage-related minor tail protein.	0.714
KLU64018.1	KLU64019.1	DEAC_c40120	DEAC_c40130	Phage tail sheath protein.	Hypothetical protein.	0.791
KLU64018.1	KLU64020.1	DEAC_c40120	DEAC_c40140	Phage tail sheath protein.	Hypothetical protein.	0.808
KLU64018.1	KLU64021.1	DEAC_c40120	DEAC_c40150	Phage tail sheath protein.	Phage head-tail joining protein.	0.861
KLU64018.1	KLU64022.1	DEAC_c40120	DEAC_c40160	Phage tail sheath protein.	Phage gp6-like head-tail connector protein.	0.786
KLU64018.1	KLU64025.1	DEAC_c40120	DEAC_c40190	Phage tail sheath protein.	Phage capsid family protein.	0.540
KLU64018.1	KLU64027.1	DEAC_c40120	DEAC_c40210	Phage tail sheath protein.	Phage portal protein.	0.446
KLU64018.1	xkdM_2	DEAC_c40120	DEAC_c40110	Phage tail sheath protein.	Phage-like element PBSX protein XkdM.	0.951
KLU64019.1	KLU64014.1	DEAC_c40130	DEAC_c40080	Hypothetical protein.	Phage-related minor tail protein.	0.618
KLU64019.1	KLU64018.1	DEAC_c40130	DEAC_c40120	Hypothetical protein.	Phage tail sheath protein.	0.791

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

27

average node degree:

4.91

avg. local clustering coefficient:

0.868

expected number of edges:

12

PPI enrichment p-value:

0.000125

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008299

Isoprenoid biosynthetic process

7 of 22

2.47

5.95

7.82e-13

GO:0018343

Protein farnesylation

2 of 2

2.96

1.5

0.0019

GO:0019408

Dolichol biosynthetic process

2 of 4

2.66

1.31

0.0041

GO:1901615

Organic hydroxy compound metabolic process

4 of 105

1.54

1.27

0.0013

GO:0016114

Terpenoid biosynthetic process

2 of 11

2.22

1.02

0.0130

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016765

Transferase activity, transferring alkyl or aryl (other than methyl) groups

8 of 41

2.25

6.02

3.64e-14

GO:0004659

Prenyltransferase activity

6 of 12

2.66

5.89

3.86e-12

GO:0004660

Protein farnesyltransferase activity

2 of 2

2.96

1.47

0.0022

GO:0004337

Geranyltranstransferase activity

2 of 2

2.96

1.47

0.0022

GO:0004161

Dimethylallyltranstransferase activity

2 of 2

2.96

1.47

0.0022

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005965

Protein farnesyltransferase complex

2 of 2

2.96

1.27

0.0051

GO:1990234

Transferase complex

5 of 345

1.12

0.78

0.0074

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:9992

Isoprenoid biosynthetic process, and Protein farnesylation

9 of 18

2.66

9.3

1.21e-19

CL:9995

Prenyltransferase activity

6 of 6

2.96

6.98

8.26e-14

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00900

Terpenoid backbone biosynthesis

8 of 30

2.39

7.12

4.13e-16

map01110

Biosynthesis of secondary metabolites

8 of 447

1.22

1.61

1.61e-07

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-446199

Synthesis of Dolichyl-phosphate

3 of 7

2.6

2.14

0.00011

MAP-446219

Synthesis of substrates in N-glycan biosythesis

3 of 22

2.1

1.55

0.0010

MAP-191273

Cholesterol biosynthesis

3 of 24

2.06

1.54

0.0010

MAP-446193

Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein

3 of 39

1.85

1.3

0.0025

MAP-2142789

Ubiquinol biosynthesis

2 of 8

2.36

1.15

0.0074

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:1904423

Dehydrodolichyl diphosphate synthase complex

2 of 2

2.96

1.21

0.0064

GOCC:0005965

Protein farnesyltransferase complex

2 of 2

2.96

1.21

0.0064

GOCC:1990234

Transferase complex

5 of 374

1.09

0.74

0.0091

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0808

Transferase

5 of 336

1.14

0.86

0.0037

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00348

Polyprenyl synthetase

3 of 3

2.96

2.61

1.78e-05

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR033749

Polyprenyl synthetase, conserved site

3 of 3

2.96

2.36

5.09e-05

IPR000092

Polyprenyl synthetase

3 of 3

2.96

2.36

5.09e-05

IPR008949

Isoprenoid synthase domain superfamily

3 of 5

2.74

2.34

5.09e-05

IPR036424

Decaprenyl diphosphate synthase-like superfamily

2 of 2

2.96

1.31

0.0043

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