citD protein (Desulfosporosinus acididurans)

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second shell of interactors

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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Score

citD

Citrate lyase acyl carrier protein; Covalent carrier of the coenzyme of citrate lyase. (90 aa)

Predicted Functional Partners:

citF

0.996

citE_2

0.994

citE_1

0.973

KLU66836.1

0.924

glpA_1

0.751

glpA_2

0.751

ydiF

0.623

KLU64329.1

0.503

cfiA

0.478

KLU64327.1

0.458

Your Current Organism:

Desulfosporosinus acididurans

NCBI taxonomy Id: 476652
Other names: D. acididurans, DSM 27692, Desulfosporosinus acididurans Sanchez-Andrea et al. 2015, Desulfosporosinus sp. D, Desulfosporosinus sp. E, Desulfosporosinus sp. M1, JCM 19471, strain M1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KLU64327.1	KLU64329.1	DEAC_c37610	DEAC_c37630	Methylaspartate ammonia-lyase.	Hypothetical protein.	0.921
KLU64327.1	citD	DEAC_c37610	DEAC_c40890	Methylaspartate ammonia-lyase.	Citrate lyase acyl carrier protein; Covalent carrier of the coenzyme of citrate lyase.	0.458
KLU64327.1	citF	DEAC_c37610	DEAC_c40910	Methylaspartate ammonia-lyase.	Citrate lyase alpha chain.	0.426
KLU64329.1	KLU64327.1	DEAC_c37630	DEAC_c37610	Hypothetical protein.	Methylaspartate ammonia-lyase.	0.921
KLU64329.1	citD	DEAC_c37630	DEAC_c40890	Hypothetical protein.	Citrate lyase acyl carrier protein; Covalent carrier of the coenzyme of citrate lyase.	0.503
KLU66836.1	cfiA	DEAC_c15040	DEAC_c16610	Hypothetical protein.	2-oxoglutarate carboxylase large subunit.	0.845
KLU66836.1	citD	DEAC_c15040	DEAC_c40890	Hypothetical protein.	Citrate lyase acyl carrier protein; Covalent carrier of the coenzyme of citrate lyase.	0.924
KLU66836.1	citE_2	DEAC_c15040	DEAC_c40900	Hypothetical protein.	Citrate lyase subunit beta; Belongs to the HpcH/HpaI aldolase family.	0.499
KLU66836.1	citF	DEAC_c15040	DEAC_c40910	Hypothetical protein.	Citrate lyase alpha chain.	0.913
cfiA	KLU66836.1	DEAC_c16610	DEAC_c15040	2-oxoglutarate carboxylase large subunit.	Hypothetical protein.	0.845
cfiA	citD	DEAC_c16610	DEAC_c40890	2-oxoglutarate carboxylase large subunit.	Citrate lyase acyl carrier protein; Covalent carrier of the coenzyme of citrate lyase.	0.478
cfiA	citE_1	DEAC_c16610	DEAC_c04760	2-oxoglutarate carboxylase large subunit.	Citrate lyase subunit beta; Belongs to the HpcH/HpaI aldolase family.	0.845
cfiA	citE_2	DEAC_c16610	DEAC_c40900	2-oxoglutarate carboxylase large subunit.	Citrate lyase subunit beta; Belongs to the HpcH/HpaI aldolase family.	0.845
cfiA	citF	DEAC_c16610	DEAC_c40910	2-oxoglutarate carboxylase large subunit.	Citrate lyase alpha chain.	0.633
cfiA	ydiF	DEAC_c16610	DEAC_c36150	2-oxoglutarate carboxylase large subunit.	Acetate CoA-transferase YdiF; Belongs to the 3-oxoacid CoA-transferase family.	0.749
citD	KLU64327.1	DEAC_c40890	DEAC_c37610	Citrate lyase acyl carrier protein; Covalent carrier of the coenzyme of citrate lyase.	Methylaspartate ammonia-lyase.	0.458
citD	KLU64329.1	DEAC_c40890	DEAC_c37630	Citrate lyase acyl carrier protein; Covalent carrier of the coenzyme of citrate lyase.	Hypothetical protein.	0.503
citD	KLU66836.1	DEAC_c40890	DEAC_c15040	Citrate lyase acyl carrier protein; Covalent carrier of the coenzyme of citrate lyase.	Hypothetical protein.	0.924
citD	cfiA	DEAC_c40890	DEAC_c16610	Citrate lyase acyl carrier protein; Covalent carrier of the coenzyme of citrate lyase.	2-oxoglutarate carboxylase large subunit.	0.478
citD	citE_1	DEAC_c40890	DEAC_c04760	Citrate lyase acyl carrier protein; Covalent carrier of the coenzyme of citrate lyase.	Citrate lyase subunit beta; Belongs to the HpcH/HpaI aldolase family.	0.973

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

37

average node degree:

6.73

avg. local clustering coefficient:

0.877

expected number of edges:

11

PPI enrichment p-value:

1.98e-10

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000103

Sulfate assimilation

7 of 9

2.99

8.05

6.82e-16

GO:0006783

Heme biosynthetic process

6 of 13

2.76

6.1

2.23e-12

GO:0006782

Protoporphyrinogen IX biosynthetic process

4 of 7

2.86

4.13

2.24e-08

GO:0070814

Hydrogen sulfide biosynthetic process

3 of 4

2.97

3.02

3.01e-06

GO:0044272

Sulfur compound biosynthetic process

4 of 58

1.94

2.2

2.26e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004783

Sulfite reductase (NADPH) activity

2 of 2

3.1

1.42

0.0027

GO:0016667

Oxidoreductase activity, acting on a sulfur group of donors

3 of 38

2.0

1.32

0.0027

GO:0016829

Lyase activity

4 of 205

1.39

0.99

0.0048

GO:0003824

Catalytic activity

11 of 3985

0.54

0.43

0.0018

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009337

Sulfite reductase complex (NADPH)

2 of 2

3.1

1.42

0.0027

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:11702

Mixed, incl. Sulfur amino acid metabolic process, and Molybdenum ion binding

11 of 109

2.1

7.26

2.31e-20

CL:11879

Heme biosynthetic process

6 of 11

2.84

6.57

3.42e-13

CL:11881

Heme biosynthetic process

5 of 5

3.1

5.98

9.61e-12

CL:11755

Sulfate assimilation

5 of 5

3.1

5.98

9.61e-12

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00860

Porphyrin and chlorophyll metabolism

6 of 55

2.14

4.29

3.83e-10

map00920

Sulfur metabolism

5 of 46

2.13

3.64

1.86e-08

map01110

Biosynthesis of secondary metabolites

7 of 669

1.12

1.26

6.63e-06

map01100

Metabolic pathways

11 of 2462

0.75

0.76

2.91e-07

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-189451

Heme biosynthesis

4 of 14

2.55

3.28

6.25e-07

MAP-189445

Metabolism of porphyrins

4 of 15

2.52

3.26

6.25e-07

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0627

Porphyrin biosynthesis

2 of 4

2.8

1.47

0.0021

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR002891

Adenylyl-sulfate kinase

2 of 2

3.1

1.1

0.0106

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