node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CUO51037.1 | CUQ14358.1 | ERS852494_00063 | ERS852494_04083 | Non-canonical purine NTP pyrophosphatase%2C rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 5'-nucleotidase/2'%2C3'-cyclic phosphodiesterase and related esterases. | 0.904 |
CUO51037.1 | guaA_1 | ERS852494_00063 | ERS852494_02963 | Non-canonical purine NTP pyrophosphatase%2C rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.959 |
CUO51037.1 | guaA_2 | ERS852494_00063 | ERS852494_03204 | Non-canonical purine NTP pyrophosphatase%2C rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | GMP synthase. | 0.952 |
CUO51037.1 | guaB | ERS852494_00063 | ERS852494_02600 | Non-canonical purine NTP pyrophosphatase%2C rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.948 |
CUO51037.1 | hpt | ERS852494_00063 | ERS852494_03073 | Non-canonical purine NTP pyrophosphatase%2C rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Putative hypoxanthine guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.909 |
CUO51037.1 | ndk | ERS852494_00063 | ERS852494_02535 | Non-canonical purine NTP pyrophosphatase%2C rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Putative nucleoside diphosphate kinase. | 0.930 |
CUO51037.1 | racE | ERS852494_00063 | ERS852494_00635 | Non-canonical purine NTP pyrophosphatase%2C rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.909 |
CUO51037.1 | surE | ERS852494_00063 | ERS852494_02456 | Non-canonical purine NTP pyrophosphatase%2C rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 5'-nucleotidase /3'-nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.904 |
CUO51037.1 | xpt | ERS852494_00063 | ERS852494_01099 | Non-canonical purine NTP pyrophosphatase%2C rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.922 |
CUO51037.1 | yfnB | ERS852494_00063 | ERS852494_03264 | Non-canonical purine NTP pyrophosphatase%2C rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Haloacid dehalogenase. | 0.902 |
CUQ14358.1 | CUO51037.1 | ERS852494_04083 | ERS852494_00063 | 5'-nucleotidase/2'%2C3'-cyclic phosphodiesterase and related esterases. | Non-canonical purine NTP pyrophosphatase%2C rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.904 |
CUQ14358.1 | guaA_1 | ERS852494_04083 | ERS852494_02963 | 5'-nucleotidase/2'%2C3'-cyclic phosphodiesterase and related esterases. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.913 |
CUQ14358.1 | guaA_2 | ERS852494_04083 | ERS852494_03204 | 5'-nucleotidase/2'%2C3'-cyclic phosphodiesterase and related esterases. | GMP synthase. | 0.913 |
CUQ14358.1 | guaB | ERS852494_04083 | ERS852494_02600 | 5'-nucleotidase/2'%2C3'-cyclic phosphodiesterase and related esterases. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.920 |
CUQ14358.1 | hpt | ERS852494_04083 | ERS852494_03073 | 5'-nucleotidase/2'%2C3'-cyclic phosphodiesterase and related esterases. | Putative hypoxanthine guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.917 |
CUQ14358.1 | surE | ERS852494_04083 | ERS852494_02456 | 5'-nucleotidase/2'%2C3'-cyclic phosphodiesterase and related esterases. | 5'-nucleotidase /3'-nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.910 |
CUQ14358.1 | xpt | ERS852494_04083 | ERS852494_01099 | 5'-nucleotidase/2'%2C3'-cyclic phosphodiesterase and related esterases. | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.907 |
CUQ14358.1 | yfnB | ERS852494_04083 | ERS852494_03264 | 5'-nucleotidase/2'%2C3'-cyclic phosphodiesterase and related esterases. | Haloacid dehalogenase. | 0.918 |
guaA_1 | CUO51037.1 | ERS852494_02963 | ERS852494_00063 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Non-canonical purine NTP pyrophosphatase%2C rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.959 |
guaA_1 | CUQ14358.1 | ERS852494_02963 | ERS852494_04083 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 5'-nucleotidase/2'%2C3'-cyclic phosphodiesterase and related esterases. | 0.913 |