| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| A9309_10645 | gcvP | A9309_10645 | A9309_12025 | Hypothetical protein; Frameshifted; Derived by automated computational analysis using gene prediction method: Protein Homology. | Glycine dehydrogenase (aminomethyl-transferring); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.778 |
| A9309_10645 | gcvT | A9309_10645 | A9309_12035 | Hypothetical protein; Frameshifted; Derived by automated computational analysis using gene prediction method: Protein Homology. | Glycine cleavage system protein T; The glycine cleavage system catalyzes the degradation of glycine. | 0.598 |
| A9309_10645 | glyA | A9309_10645 | A9309_03870 | Hypothetical protein; Frameshifted; Derived by automated computational analysis using gene prediction method: Protein Homology. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.671 |
| A9309_10645 | ilvA | A9309_10645 | A9309_02755 | Hypothetical protein; Frameshifted; Derived by automated computational analysis using gene prediction method: Protein Homology. | PLP-dependent threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.551 |
| A9309_10645 | ltaE | A9309_10645 | A9309_02340 | Hypothetical protein; Frameshifted; Derived by automated computational analysis using gene prediction method: Protein Homology. | Threonine aldolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.635 |
| A9309_10645 | serB | A9309_10645 | A9309_02125 | Hypothetical protein; Frameshifted; Derived by automated computational analysis using gene prediction method: Protein Homology. | Phosphoserine phosphatase SerB; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.740 |
| A9309_10645 | thrC | A9309_10645 | A9309_11940 | Hypothetical protein; Frameshifted; Derived by automated computational analysis using gene prediction method: Protein Homology. | Threonine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.506 |
| folC | gcvT | A9309_02575 | A9309_12035 | Bifunctional folylpolyglutamate synthase/dihydrofolate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the folylpolyglutamate synthase family. | Glycine cleavage system protein T; The glycine cleavage system catalyzes the degradation of glycine. | 0.608 |
| folC | glyA | A9309_02575 | A9309_03870 | Bifunctional folylpolyglutamate synthase/dihydrofolate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the folylpolyglutamate synthase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.969 |
| folC | ltaE | A9309_02575 | A9309_02340 | Bifunctional folylpolyglutamate synthase/dihydrofolate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the folylpolyglutamate synthase family. | Threonine aldolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.578 |
| gcvP | A9309_10645 | A9309_12025 | A9309_10645 | Glycine dehydrogenase (aminomethyl-transferring); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Hypothetical protein; Frameshifted; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.778 |
| gcvP | gcvT | A9309_12025 | A9309_12035 | Glycine dehydrogenase (aminomethyl-transferring); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Glycine cleavage system protein T; The glycine cleavage system catalyzes the degradation of glycine. | 0.999 |
| gcvP | glyA | A9309_12025 | A9309_03870 | Glycine dehydrogenase (aminomethyl-transferring); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.997 |
| gcvP | ltaE | A9309_12025 | A9309_02340 | Glycine dehydrogenase (aminomethyl-transferring); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Threonine aldolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.929 |
| gcvP | thrC | A9309_12025 | A9309_11940 | Glycine dehydrogenase (aminomethyl-transferring); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Threonine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.417 |
| gcvP | ydfG | A9309_12025 | A9309_01035 | Glycine dehydrogenase (aminomethyl-transferring); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | NADP-dependent 3-hydroxy acid dehydrogenase; NADP(+)-dependent; catalyzes the formation of 3-hydroxypropionate from the toxic malonic semialdehyde, catalyzes the formation of 2-aminomalonate-semialdehyde from L-serine; can also use 3-hydroxybutyrate, 3-hydroxy-isobutyrate, D-threonine, L-allo-threonine,D-serine; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.726 |
| gcvT | A9309_10645 | A9309_12035 | A9309_10645 | Glycine cleavage system protein T; The glycine cleavage system catalyzes the degradation of glycine. | Hypothetical protein; Frameshifted; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.598 |
| gcvT | folC | A9309_12035 | A9309_02575 | Glycine cleavage system protein T; The glycine cleavage system catalyzes the degradation of glycine. | Bifunctional folylpolyglutamate synthase/dihydrofolate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the folylpolyglutamate synthase family. | 0.608 |
| gcvT | gcvP | A9309_12035 | A9309_12025 | Glycine cleavage system protein T; The glycine cleavage system catalyzes the degradation of glycine. | Glycine dehydrogenase (aminomethyl-transferring); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.999 |
| gcvT | glyA | A9309_12035 | A9309_03870 | Glycine cleavage system protein T; The glycine cleavage system catalyzes the degradation of glycine. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.996 |