STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KYC_05806COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase. (280 aa)    
Predicted Functional Partners:
KYC_05766
TENA/THI-4/PQQC family protein 2; Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway; Belongs to the TenA family.
 
 0.999
thiE
Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
 
 0.999
thiC
Thiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
 
 
 0.993
thiG
Thiazole synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
 
  
 0.982
KYC_19004
COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase.
  
  
 
0.970
KYC_25533
COG2104 Sulfur transfer protein involved in thiamine biosynthesis.
 
 
  0.918
KYC_19174
Hypothetical protein; COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes; Belongs to the Nudix hydrolase family.
 
 
 0.909
KYC_14797
Hypothetical protein.
 
 
 0.843
KYC_23318
Molybdopterin biosynthesis protein MoeB; COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2.
 
  
 0.716
pdxK
Pyridoxal-pyridoxamine kinase/hydroxymethylpyrimidine kinase; COG2240 Pyridoxal/pyridoxine/pyridoxamine kinase; Belongs to the pyridoxine kinase family.
  
 
 0.630
Your Current Organism:
Achromobacter arsenitoxydans
NCBI taxonomy Id: 477184
Other names: A. arsenitoxydans SY8, Achromobacter arsenitoxydans SY8, Achromobacter arsenitoxydans str. SY8, Achromobacter arsenitoxydans strain SY8, Achromobacter sp. SY8, arsenite-oxidizing bacterium SY8
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.