node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
KYC_20224 | KYC_25418 | KYC_20224 | KYC_25418 | Nucleoside-triphosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | COG0518 GMP synthase - Glutamine amidotransferase domain. | 0.925 |
KYC_20224 | KYC_28242 | KYC_20224 | KYC_28242 | Nucleoside-triphosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Putative 5'(3')-deoxyribonucleotidase; COG4502 Uncharacterized protein conserved in bacteria. | 0.922 |
KYC_20224 | apt | KYC_20224 | KYC_23103 | Nucleoside-triphosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.575 |
KYC_20224 | gmk | KYC_20224 | KYC_07156 | Nucleoside-triphosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.638 |
KYC_20224 | guaA | KYC_20224 | KYC_02309 | Nucleoside-triphosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.980 |
KYC_20224 | guaB | KYC_20224 | KYC_02314 | Nucleoside-triphosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.924 |
KYC_20224 | surE | KYC_20224 | KYC_06921 | Nucleoside-triphosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 5'(3')-nucleotidase/polyphosphatase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.922 |
KYC_25418 | KYC_20224 | KYC_25418 | KYC_20224 | COG0518 GMP synthase - Glutamine amidotransferase domain. | Nucleoside-triphosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.925 |
KYC_25418 | KYC_28242 | KYC_25418 | KYC_28242 | COG0518 GMP synthase - Glutamine amidotransferase domain. | Putative 5'(3')-deoxyribonucleotidase; COG4502 Uncharacterized protein conserved in bacteria. | 0.922 |
KYC_25418 | apt | KYC_25418 | KYC_23103 | COG0518 GMP synthase - Glutamine amidotransferase domain. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.954 |
KYC_25418 | argS | KYC_25418 | KYC_06621 | COG0518 GMP synthase - Glutamine amidotransferase domain. | COG0018 Arginyl-tRNA synthetase. | 0.718 |
KYC_25418 | gatB | KYC_25418 | KYC_05596 | COG0518 GMP synthase - Glutamine amidotransferase domain. | aspartyl/glutamyl-tRNA amidotransferase subunit B; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatB/GatE family. GatB subfamily. | 0.764 |
KYC_25418 | gmk | KYC_25418 | KYC_07156 | COG0518 GMP synthase - Glutamine amidotransferase domain. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.967 |
KYC_25418 | guaA | KYC_25418 | KYC_02309 | COG0518 GMP synthase - Glutamine amidotransferase domain. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.946 |
KYC_25418 | guaB | KYC_25418 | KYC_02314 | COG0518 GMP synthase - Glutamine amidotransferase domain. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.981 |
KYC_25418 | purL | KYC_25418 | KYC_04852 | COG0518 GMP synthase - Glutamine amidotransferase domain. | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.708 |
KYC_25418 | surE | KYC_25418 | KYC_06921 | COG0518 GMP synthase - Glutamine amidotransferase domain. | 5'(3')-nucleotidase/polyphosphatase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.938 |
KYC_28242 | KYC_20224 | KYC_28242 | KYC_20224 | Putative 5'(3')-deoxyribonucleotidase; COG4502 Uncharacterized protein conserved in bacteria. | Nucleoside-triphosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.922 |
KYC_28242 | KYC_25418 | KYC_28242 | KYC_25418 | Putative 5'(3')-deoxyribonucleotidase; COG4502 Uncharacterized protein conserved in bacteria. | COG0518 GMP synthase - Glutamine amidotransferase domain. | 0.922 |
KYC_28242 | gmk | KYC_28242 | KYC_07156 | Putative 5'(3')-deoxyribonucleotidase; COG4502 Uncharacterized protein conserved in bacteria. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.922 |