| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CCH89510.1 | dnaK | MODMU_4109 | MODMU_5179 | Putative exonuclease, RNase T and DNA polymerase III; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Chaperone protein dnaK (Heat shock protein 70) (Heat shock 70 kDa protein) (HSP70); Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.424 |
| CCH89510.1 | dnaN | MODMU_4109 | MODMU_0003 | Putative exonuclease, RNase T and DNA polymerase III; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.959 |
| CCH89510.1 | ftsZ | MODMU_4109 | MODMU_3451 | Putative exonuclease, RNase T and DNA polymerase III; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Cell division protein ftsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. | 0.460 |
| CCH89510.1 | gyrA | MODMU_4109 | MODMU_0011 | Putative exonuclease, RNase T and DNA polymerase III; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | DNA gyrase subunit A; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.918 |
| CCH89510.1 | gyrB | MODMU_4109 | MODMU_0010 | Putative exonuclease, RNase T and DNA polymerase III; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.535 |
| CCH89510.1 | metH | MODMU_4109 | MODMU_2592 | Putative exonuclease, RNase T and DNA polymerase III; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | B12-dependent homocysteine-N5-methyltetrahydrofolate transmethylase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.607 |
| CCH89510.1 | polC | MODMU_4109 | MODMU_3525 | Putative exonuclease, RNase T and DNA polymerase III; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | DNA-directed DNA polymerase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.981 |
| CCH89510.1 | radA | MODMU_4109 | MODMU_0754 | Putative exonuclease, RNase T and DNA polymerase III; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | DNA repair protein radA homolog; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. | 0.677 |
| CCH89510.1 | rpoB | MODMU_4109 | MODMU_4930 | Putative exonuclease, RNase T and DNA polymerase III; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.531 |
| dnaK | CCH89510.1 | MODMU_5179 | MODMU_4109 | Chaperone protein dnaK (Heat shock protein 70) (Heat shock 70 kDa protein) (HSP70); Acts as a chaperone; Belongs to the heat shock protein 70 family. | Putative exonuclease, RNase T and DNA polymerase III; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.424 |
| dnaK | ftsZ | MODMU_5179 | MODMU_3451 | Chaperone protein dnaK (Heat shock protein 70) (Heat shock 70 kDa protein) (HSP70); Acts as a chaperone; Belongs to the heat shock protein 70 family. | Cell division protein ftsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. | 0.698 |
| dnaK | gyrA | MODMU_5179 | MODMU_0011 | Chaperone protein dnaK (Heat shock protein 70) (Heat shock 70 kDa protein) (HSP70); Acts as a chaperone; Belongs to the heat shock protein 70 family. | DNA gyrase subunit A; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.893 |
| dnaK | gyrB | MODMU_5179 | MODMU_0010 | Chaperone protein dnaK (Heat shock protein 70) (Heat shock 70 kDa protein) (HSP70); Acts as a chaperone; Belongs to the heat shock protein 70 family. | DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.914 |
| dnaK | radA | MODMU_5179 | MODMU_0754 | Chaperone protein dnaK (Heat shock protein 70) (Heat shock 70 kDa protein) (HSP70); Acts as a chaperone; Belongs to the heat shock protein 70 family. | DNA repair protein radA homolog; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. | 0.678 |
| dnaK | rpoB | MODMU_5179 | MODMU_4930 | Chaperone protein dnaK (Heat shock protein 70) (Heat shock 70 kDa protein) (HSP70); Acts as a chaperone; Belongs to the heat shock protein 70 family. | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.777 |
| dnaN | CCH89510.1 | MODMU_0003 | MODMU_4109 | DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Putative exonuclease, RNase T and DNA polymerase III; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.959 |
| dnaN | ftsZ | MODMU_0003 | MODMU_3451 | DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Cell division protein ftsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. | 0.512 |
| dnaN | gyrA | MODMU_0003 | MODMU_0011 | DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA gyrase subunit A; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.918 |
| dnaN | gyrB | MODMU_0003 | MODMU_0010 | DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.862 |
| dnaN | polC | MODMU_0003 | MODMU_3525 | DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA-directed DNA polymerase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.954 |
