STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mutMDNA-(Apurinic or apyrimidinic site) lyase; Function of strongly homologous gene; enzyme; Belongs to the FPG family. (289 aa)    
Predicted Functional Partners:
mutM-2
Formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
  
  
0.930
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
  
 0.876
CCH89713.1
DNA glycosylase; Function of strongly homologous gene; enzyme.
  
   
 0.835
CCH89714.1
DNA glycosylase; Function of strongly homologous gene; enzyme.
  
   
 0.835
lig
ATP-dependent DNA ligase; Function of strongly homologous gene; enzyme.
 
  
 0.641
CCH89345.1
Homologs of previously reported genes of unknown function.
  
  
 0.559
CCH88046.1
5'-3' exonuclease; Function of strongly homologous gene; enzyme.
 
  
 0.549
CCH89086.1
Putative DNA polymerase LigD; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
 
     0.532
CCH85681.1
NAD-dependent malic enzyme; Function of strongly homologous gene; enzyme.
       0.520
CCH85682.1
Cysteine-S-conjugate beta-lyase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative regulator.
       0.520
Your Current Organism:
Modestobacter marinus
NCBI taxonomy Id: 477641
Other names: CGMCC 4.5581, DSM 45201, M. marinus, Modestobacter marinus Xiao et al. 2011, Modestobacter sp. 42H12-1, strain 42H12-1
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.