STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CCH86438.1L-threonine ammonia-lyase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (408 aa)    
Predicted Functional Partners:
ilvH
Acetolactate synthase small subunit (AHAS) (Acetohydroxy-acid synthase small subunit) (ALS); Function of homologous gene experimentally demonstrated in an other organism; enzyme.
  
 
 0.980
cbs
Cystathionine beta-synthase; Function of strongly homologous gene; enzyme.
 
 
 0.960
ilvI
Acetolactate synthase large subunit (AHAS) (Acetohydroxy-acid synthase large subunit) (ALS); Function of homologous gene experimentally demonstrated in an other organism; enzyme.
 
 0.958
leuB
3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily.
  
 
 0.951
CCH86655.1
Putative thiamine pyrophosphate-dependent decarboxylase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
  
 0.947
thrC
L-threonine synthase; Function of strongly homologous gene; enzyme.
  
 
 0.944
thrC-2
Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine.
  
 
0.944
ltaA
L-allo-threonine aldolase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
   
 
 0.936
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
    
 0.930
glyA-2
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
    
 0.930
Your Current Organism:
Modestobacter marinus
NCBI taxonomy Id: 477641
Other names: CGMCC 4.5581, DSM 45201, M. marinus, Modestobacter marinus Xiao et al. 2011, Modestobacter sp. 42H12-1, strain 42H12-1
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