STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sdhASuccinate dehydrogenase subunit A; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (648 aa)    
Predicted Functional Partners:
sdhB
Succinate dehydrogenase subunit B; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
 0.999
sdhC
Succinate dehydrogenase/fumarate reductase cytochrome b subunit, b558 family; Function of strongly homologous gene; enzyme.
 
 0.999
CCH87852.1
Succinate dehydrogenase and fumarate reductase iron-sulfur protein; Function of strongly homologous gene; enzyme.
  
 0.997
sucC
Succinyl-CoA ligase [ADP-forming] subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
 0.987
sucA
2-oxoglutarate decarboxylase; Function of strongly homologous gene; enzyme.
 
 0.986
fumC
Fumarate hydratase class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
 
 0.975
sucD-2
succinyl-CoA synthetase, alpha subunit, NAD(P)-binding; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
 0.968
gabD
Succinate-semialdehyde dehydrogenase [NADP+] 1; Function of strongly homologous gene; enzyme.
  
 0.928
gabD1
Succinate-semialdehyde dehydrogenase [NADP+]; Function of strongly homologous gene; enzyme.
  
 0.928
CCH89975.1
Succinate-semialdehyde dehydrogenase [NADP+]; Function of strongly homologous gene; enzyme.
  
 0.928
Your Current Organism:
Modestobacter marinus
NCBI taxonomy Id: 477641
Other names: CGMCC 4.5581, DSM 45201, M. marinus, Modestobacter marinus Xiao et al. 2011, Modestobacter sp. 42H12-1, strain 42H12-1
Server load: high (96%) [ZH]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.