STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
metE5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; Function of strongly homologous gene; enzyme. (344 aa)    
Predicted Functional Partners:
metH
B12-dependent homocysteine-N5-methyltetrahydrofolate transmethylase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
  
 
 0.928
metK
Methionine adenosyltransferase 1 (AdoMet synthetase); Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
  
 0.927
ahcY
Adenosylhomocysteinase (S-adenosyl-L-homocysteine hydrolase) (AdoHcyase); May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
  
 
 0.915
CCH89838.1
Putative cystathionine gamma-lyase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
  
 
 0.794
metB
Cystathionine gamma-synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
  
 
 0.794
metC
O-acetylhomoserine/O-acetylserine sulfhydrylase; Function of strongly homologous gene; enzyme.
  
 
 0.775
CCH86438.1
L-threonine ammonia-lyase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
 
 
 0.750
hom
Homoserine dehydrogenase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
  
 
 0.748
cbs
Cystathionine beta-synthase; Function of strongly homologous gene; enzyme.
  
 
 0.746
metF
5,10-methylenetetrahydrofolate reductase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the methylenetetrahydrofolate reductase family.
  
 
 0.744
Your Current Organism:
Modestobacter marinus
NCBI taxonomy Id: 477641
Other names: CGMCC 4.5581, DSM 45201, M. marinus, Modestobacter marinus Xiao et al. 2011, Modestobacter sp. 42H12-1, strain 42H12-1
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