STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CCH86852.1Nucleoside-triphosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (207 aa)    
Predicted Functional Partners:
rph
RNase PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
 
    0.992
guaA
GMP synthase [glutamine-hydrolyzing] (Glutamine amidotransferase) (GMP synthetase); Catalyzes the synthesis of GMP from XMP.
 
 
 0.980
CCH85747.1
IMP dehydrogenase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
 
 0.954
guaB
Inosine-5'-monophosphate dehydrogenase (IMP dehydrogenase) (IMPDH) (IMPD); Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
 
 0.943
ndk
Nucleoside diphosphate kinase (NDK) (NDP kinase) (Nucleoside-2-P kinase); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
  
 0.933
CCH90233.1
Inosine monophosphate dehydrogenase; Function of strongly homologous gene; enzyme.
  
 0.923
CCH86423.1
Nucleoside triphosphate pyrophosphohydrolase MazG; Function of strongly homologous gene; enzyme.
 
  
  0.921
CCH87339.1
Putative GMP synthase family protein (modular protein); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology.
  
 
 0.912
hpt
Hypoxanthine-guanine phosphoribosyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
  
 
 0.909
CCH89880.1
Putative 5'-nucleotidase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the 5'-nucleotidase family.
  
 
  0.902
Your Current Organism:
Modestobacter marinus
NCBI taxonomy Id: 477641
Other names: CGMCC 4.5581, DSM 45201, M. marinus, Modestobacter marinus Xiao et al. 2011, Modestobacter sp. 42H12-1, strain 42H12-1
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