STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
hemKMethyltransferase HemK; Function of strongly homologous gene; enzyme. (250 aa)    
Predicted Functional Partners:
prfA
Peptide chain release factor 1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
 
 
 0.953
CCH87539.1
Homologs of previously reported genes of unknown function; Belongs to the D-glutamate cyclase family.
       0.773
gcvP
Glycine cleavage system P-protein (glycine dehydrogenase); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.
     
  0.748
metH
B12-dependent homocysteine-N5-methyltetrahydrofolate transmethylase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
     
  0.741
cbs
Cystathionine beta-synthase; Function of strongly homologous gene; enzyme.
    
  0.687
CCH89933.1
Putative translation factor; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative factor; Belongs to the SUA5 family.
 
  
 0.599
ahs
Allophanate hydrolase, subunit2; Function of strongly homologous gene; enzyme.
       0.536
CCH87536.1
Allophanate hydrolase subunit 1; Function of strongly homologous gene; enzyme.
       0.536
pxpA
Putative lactam utilization protein; Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
       0.536
CCH87538.1
Mn2+/Fe2_transporter, NRAMP family; Function of strongly homologous gene; transporter.
       0.536
Your Current Organism:
Modestobacter marinus
NCBI taxonomy Id: 477641
Other names: CGMCC 4.5581, DSM 45201, M. marinus, Modestobacter marinus Xiao et al. 2011, Modestobacter sp. 42H12-1, strain 42H12-1
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