| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CCH88279.1 | gcvH | MODMU_2850 | MODMU_2671 | 5,10-methylenetetrahydrofolate reductase; Function of strongly homologous gene; enzyme; Belongs to the methylenetetrahydrofolate reductase family. | Glycine cleavage system H-protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.911 |
| CCH88279.1 | gcvP | MODMU_2850 | MODMU_2666 | 5,10-methylenetetrahydrofolate reductase; Function of strongly homologous gene; enzyme; Belongs to the methylenetetrahydrofolate reductase family. | Glycine cleavage system P-protein (glycine dehydrogenase); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.943 |
| CCH88279.1 | gcvT | MODMU_2850 | MODMU_2841 | 5,10-methylenetetrahydrofolate reductase; Function of strongly homologous gene; enzyme; Belongs to the methylenetetrahydrofolate reductase family. | Aminomethyltransferase; Function of strongly homologous gene; enzyme; Belongs to the GcvT family. | 0.754 |
| CCH88279.1 | gcvT-2 | MODMU_2850 | MODMU_2842 | 5,10-methylenetetrahydrofolate reductase; Function of strongly homologous gene; enzyme; Belongs to the methylenetetrahydrofolate reductase family. | Aminomethyltransferase; Function of strongly homologous gene; enzyme; Belongs to the GcvT family. | 0.769 |
| CCH88279.1 | gltB | MODMU_2850 | MODMU_3403 | 5,10-methylenetetrahydrofolate reductase; Function of strongly homologous gene; enzyme; Belongs to the methylenetetrahydrofolate reductase family. | Glutamate synthase [NADPH] large chain (NADPH-GOGAT); Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.664 |
| CCH88279.1 | glyA | MODMU_2850 | MODMU_3071 | 5,10-methylenetetrahydrofolate reductase; Function of strongly homologous gene; enzyme; Belongs to the methylenetetrahydrofolate reductase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.726 |
| CCH88279.1 | glyA-2 | MODMU_2850 | MODMU_4549 | 5,10-methylenetetrahydrofolate reductase; Function of strongly homologous gene; enzyme; Belongs to the methylenetetrahydrofolate reductase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.726 |
| CCH88279.1 | glyA-3 | MODMU_2850 | MODMU_5350 | 5,10-methylenetetrahydrofolate reductase; Function of strongly homologous gene; enzyme; Belongs to the methylenetetrahydrofolate reductase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.726 |
| gcvH | CCH88279.1 | MODMU_2671 | MODMU_2850 | Glycine cleavage system H-protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 5,10-methylenetetrahydrofolate reductase; Function of strongly homologous gene; enzyme; Belongs to the methylenetetrahydrofolate reductase family. | 0.911 |
| gcvH | gcvP | MODMU_2671 | MODMU_2666 | Glycine cleavage system H-protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Glycine cleavage system P-protein (glycine dehydrogenase); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.999 |
| gcvH | gcvT | MODMU_2671 | MODMU_2841 | Glycine cleavage system H-protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Aminomethyltransferase; Function of strongly homologous gene; enzyme; Belongs to the GcvT family. | 0.966 |
| gcvH | gcvT-2 | MODMU_2671 | MODMU_2842 | Glycine cleavage system H-protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Aminomethyltransferase; Function of strongly homologous gene; enzyme; Belongs to the GcvT family. | 0.964 |
| gcvH | gltB | MODMU_2671 | MODMU_3403 | Glycine cleavage system H-protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Glutamate synthase [NADPH] large chain (NADPH-GOGAT); Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.961 |
| gcvH | glyA | MODMU_2671 | MODMU_3071 | Glycine cleavage system H-protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.954 |
| gcvH | glyA-2 | MODMU_2671 | MODMU_4549 | Glycine cleavage system H-protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.954 |
| gcvH | glyA-3 | MODMU_2671 | MODMU_5350 | Glycine cleavage system H-protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.951 |
| gcvP | CCH88279.1 | MODMU_2666 | MODMU_2850 | Glycine cleavage system P-protein (glycine dehydrogenase); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 5,10-methylenetetrahydrofolate reductase; Function of strongly homologous gene; enzyme; Belongs to the methylenetetrahydrofolate reductase family. | 0.943 |
| gcvP | gcvH | MODMU_2666 | MODMU_2671 | Glycine cleavage system P-protein (glycine dehydrogenase); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Glycine cleavage system H-protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.999 |
| gcvP | gcvT | MODMU_2666 | MODMU_2841 | Glycine cleavage system P-protein (glycine dehydrogenase); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Aminomethyltransferase; Function of strongly homologous gene; enzyme; Belongs to the GcvT family. | 0.994 |
| gcvP | gcvT-2 | MODMU_2666 | MODMU_2842 | Glycine cleavage system P-protein (glycine dehydrogenase); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Aminomethyltransferase; Function of strongly homologous gene; enzyme; Belongs to the GcvT family. | 0.994 |
