sdaA-2 protein (Modestobacter marinus) - STRING interaction network

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[Homology]

Score

sdaA-2

L-serine ammonia-lyase; Function of strongly homologous gene; enzyme; Belongs to the iron-sulfur dependent L-serine dehydratase family. (456 aa)

Predicted Functional Partners:

glyA

0.891

soxA-2

0.828

serB

0.826

soxG-2

0.821

soxD-2

0.816

CCH86438.1

0.815

cbs

0.789

gcvP

0.764

soxB-2

0.701

thrB

0.677

Your Current Organism:

Modestobacter marinus

NCBI taxonomy Id: 477641
Other names: CGMCC 4.5581, DSM 45201, M. marinus, Modestobacter marinus Xiao et al. 2011, Modestobacter sp. 42H12-1, strain 42H12-1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCH86438.1	cbs	MODMU_0988	MODMU_4605	L-threonine ammonia-lyase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.	Cystathionine beta-synthase; Function of strongly homologous gene; enzyme.	0.965
CCH86438.1	gcvP	MODMU_0988	MODMU_2666	L-threonine ammonia-lyase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.	Glycine cleavage system P-protein (glycine dehydrogenase); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.	0.449
CCH86438.1	glyA	MODMU_0988	MODMU_3071	L-threonine ammonia-lyase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.767
CCH86438.1	sdaA-2	MODMU_0988	MODMU_3076	L-threonine ammonia-lyase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.	L-serine ammonia-lyase; Function of strongly homologous gene; enzyme; Belongs to the iron-sulfur dependent L-serine dehydratase family.	0.815
CCH86438.1	serB	MODMU_0988	MODMU_1384	L-threonine ammonia-lyase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.	Phosphoserine phosphatase; Function of strongly homologous gene; enzyme.	0.920
CCH86438.1	thrB	MODMU_0988	MODMU_4557	L-threonine ammonia-lyase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.	Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily.	0.556
cbs	CCH86438.1	MODMU_4605	MODMU_0988	Cystathionine beta-synthase; Function of strongly homologous gene; enzyme.	L-threonine ammonia-lyase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.	0.965
cbs	glyA	MODMU_4605	MODMU_3071	Cystathionine beta-synthase; Function of strongly homologous gene; enzyme.	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.797
cbs	sdaA-2	MODMU_4605	MODMU_3076	Cystathionine beta-synthase; Function of strongly homologous gene; enzyme.	L-serine ammonia-lyase; Function of strongly homologous gene; enzyme; Belongs to the iron-sulfur dependent L-serine dehydratase family.	0.789
cbs	serB	MODMU_4605	MODMU_1384	Cystathionine beta-synthase; Function of strongly homologous gene; enzyme.	Phosphoserine phosphatase; Function of strongly homologous gene; enzyme.	0.950
cbs	thrB	MODMU_4605	MODMU_4557	Cystathionine beta-synthase; Function of strongly homologous gene; enzyme.	Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily.	0.793
gcvP	CCH86438.1	MODMU_2666	MODMU_0988	Glycine cleavage system P-protein (glycine dehydrogenase); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.	L-threonine ammonia-lyase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.	0.449
gcvP	glyA	MODMU_2666	MODMU_3071	Glycine cleavage system P-protein (glycine dehydrogenase); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.995
gcvP	sdaA-2	MODMU_2666	MODMU_3076	Glycine cleavage system P-protein (glycine dehydrogenase); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.	L-serine ammonia-lyase; Function of strongly homologous gene; enzyme; Belongs to the iron-sulfur dependent L-serine dehydratase family.	0.764
gcvP	soxA-2	MODMU_2666	MODMU_3074	Glycine cleavage system P-protein (glycine dehydrogenase); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.	Sarcosine oxidase, alpha subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme.	0.987
gcvP	soxB-2	MODMU_2666	MODMU_3072	Glycine cleavage system P-protein (glycine dehydrogenase); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.	Sarcosine oxidase, beta subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme.	0.717
gcvP	soxD-2	MODMU_2666	MODMU_3073	Glycine cleavage system P-protein (glycine dehydrogenase); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.	Sarcosine oxidase subunit delta; Function of strongly homologous gene; enzyme.	0.769
gcvP	soxG-2	MODMU_2666	MODMU_3075	Glycine cleavage system P-protein (glycine dehydrogenase); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.	Sarcosine oxidase subunit gamma; Function of strongly homologous gene; enzyme.	0.773
glyA	CCH86438.1	MODMU_3071	MODMU_0988	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	L-threonine ammonia-lyase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.	0.767
glyA	cbs	MODMU_3071	MODMU_4605	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Cystathionine beta-synthase; Function of strongly homologous gene; enzyme.	0.797

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