STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
CCH88504.1Dihydropteroate synthase 1 (fragment); Function of strongly homologous gene; enzyme. (211 aa)    
Predicted Functional Partners:
folB
Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin.
 
 0.991
folK
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase; Function of strongly homologous gene; enzyme.
 
 
 0.990
folE
GTP cyclohydrolase I; Function of strongly homologous gene; enzyme.
 
 
 0.957
CCH88505.1
Para-aminobenzoate synthase, subunit I (fragment); Function of strongly homologous gene; enzyme.
 
 
 0.937
folC
Folylpolyglutamate synthase/dihydrofolate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the folylpolyglutamate synthase family.
 
 
 0.893
pab
Para-aminobenzoate synthase; Function of strongly homologous gene; enzyme.
 
 
 0.876
folP
Dihydropteroate synthase 2; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
  
  
0.743
CCH90413.1
Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase; Function of strongly homologous gene; enzyme.
 
 
 0.738
guaB
Inosine-5'-monophosphate dehydrogenase (IMP dehydrogenase) (IMPDH) (IMPD); Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
  
  
 0.562
ribH
6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
 
  
 0.559
Your Current Organism:
Modestobacter marinus
NCBI taxonomy Id: 477641
Other names: CGMCC 4.5581, DSM 45201, M. marinus, Modestobacter marinus Xiao et al. 2011, Modestobacter sp. 42H12-1, strain 42H12-1
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