node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCH88591.1 | CCH88592.1 | MODMU_3167 | MODMU_3168 | Transcriptional regulator, AraC family; Function of strongly homologous gene; regulator. | Homologs of previously reported genes of unknown function. | 0.536 |
CCH88591.1 | ald | MODMU_3167 | MODMU_3165 | Transcriptional regulator, AraC family; Function of strongly homologous gene; regulator. | Alanine dehydrogenase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the AlaDH/PNT family. | 0.472 |
CCH88591.1 | ribD | MODMU_3167 | MODMU_3166 | Transcriptional regulator, AraC family; Function of strongly homologous gene; regulator. | Riboflavin biosynthesis protein ribD; Function of strongly homologous gene; enzyme. | 0.951 |
CCH88592.1 | CCH88591.1 | MODMU_3168 | MODMU_3167 | Homologs of previously reported genes of unknown function. | Transcriptional regulator, AraC family; Function of strongly homologous gene; regulator. | 0.536 |
CCH88592.1 | ribD | MODMU_3168 | MODMU_3166 | Homologs of previously reported genes of unknown function. | Riboflavin biosynthesis protein ribD; Function of strongly homologous gene; enzyme. | 0.536 |
CCH88680.1 | ribD | MODMU_3267 | MODMU_3166 | Bifunctional deaminase-reductase domain protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Riboflavin biosynthesis protein ribD; Function of strongly homologous gene; enzyme. | 0.598 |
CCH88680.1 | thyA | MODMU_3267 | MODMU_4341 | Bifunctional deaminase-reductase domain protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Thymidylate synthase (TS) (TSase); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.474 |
ald | CCH88591.1 | MODMU_3165 | MODMU_3167 | Alanine dehydrogenase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the AlaDH/PNT family. | Transcriptional regulator, AraC family; Function of strongly homologous gene; regulator. | 0.472 |
ald | gcvP | MODMU_3165 | MODMU_2666 | Alanine dehydrogenase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the AlaDH/PNT family. | Glycine cleavage system P-protein (glycine dehydrogenase); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.465 |
ald | ribD | MODMU_3165 | MODMU_3166 | Alanine dehydrogenase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the AlaDH/PNT family. | Riboflavin biosynthesis protein ribD; Function of strongly homologous gene; enzyme. | 0.472 |
folC | gcvP | MODMU_1713 | MODMU_2666 | Folylpolyglutamate synthase/dihydrofolate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the folylpolyglutamate synthase family. | Glycine cleavage system P-protein (glycine dehydrogenase); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.483 |
folC | ribD | MODMU_1713 | MODMU_3166 | Folylpolyglutamate synthase/dihydrofolate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the folylpolyglutamate synthase family. | Riboflavin biosynthesis protein ribD; Function of strongly homologous gene; enzyme. | 0.526 |
folC | thyA | MODMU_1713 | MODMU_4341 | Folylpolyglutamate synthase/dihydrofolate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the folylpolyglutamate synthase family. | Thymidylate synthase (TS) (TSase); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.937 |
gcvH | gcvP | MODMU_2671 | MODMU_2666 | Glycine cleavage system H-protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Glycine cleavage system P-protein (glycine dehydrogenase); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.999 |
gcvH | gcvT-3 | MODMU_2671 | MODMU_3546 | Glycine cleavage system H-protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.998 |
gcvH | ribD | MODMU_2671 | MODMU_3166 | Glycine cleavage system H-protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Riboflavin biosynthesis protein ribD; Function of strongly homologous gene; enzyme. | 0.524 |
gcvH | thyA | MODMU_2671 | MODMU_4341 | Glycine cleavage system H-protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Thymidylate synthase (TS) (TSase); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.660 |
gcvP | ald | MODMU_2666 | MODMU_3165 | Glycine cleavage system P-protein (glycine dehydrogenase); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Alanine dehydrogenase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the AlaDH/PNT family. | 0.465 |
gcvP | folC | MODMU_2666 | MODMU_1713 | Glycine cleavage system P-protein (glycine dehydrogenase); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Folylpolyglutamate synthase/dihydrofolate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the folylpolyglutamate synthase family. | 0.483 |
gcvP | gcvH | MODMU_2666 | MODMU_2671 | Glycine cleavage system P-protein (glycine dehydrogenase); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Glycine cleavage system H-protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.999 |