STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pfkA-26-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (341 aa)    
Predicted Functional Partners:
pgi
Glucose-6-phosphate isomerase 1; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the GPI family.
  
 0.988
fba
Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family.
 
 
 0.965
glpX
Fructose 1,6-bisphosphatase II; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
   
 
 0.936
tkt
Transketolase; Function of strongly homologous gene; enzyme; Belongs to the transketolase family.
  
 
 0.935
talB
Transaldolase; Function of strongly homologous gene; enzyme.
  
 
 0.933
tal
Transaldolase subfamily; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 2 subfamily.
  
 
 0.933
fruK
1-phosphofructokinase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the carbohydrate kinase PfkB family.
  
  
 0.925
frk
Sugar kinase, ribokinase; Function of strongly homologous gene; enzyme.
  
 
 0.916
CCH87902.1
Ribokinase; Function of strongly homologous gene; enzyme; Belongs to the carbohydrate kinase PfkB family.
  
 
 0.916
pyk
Pyruvate kinase; Function of strongly homologous gene; enzyme; Belongs to the pyruvate kinase family.
 
 0.916
Your Current Organism:
Modestobacter marinus
NCBI taxonomy Id: 477641
Other names: CGMCC 4.5581, DSM 45201, M. marinus, Modestobacter marinus Xiao et al. 2011, Modestobacter sp. 42H12-1, strain 42H12-1
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.