STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
icdIsocitrate dehydrogenase [NADP] (Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (404 aa)    
Predicted Functional Partners:
sucA
2-oxoglutarate decarboxylase; Function of strongly homologous gene; enzyme.
  
 
 0.996
acnA
Aconitate hydratase 1; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
  
 0.989
mdh
Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate.
  
 
 0.959
gltB
Glutamate synthase [NADPH] large chain (NADPH-GOGAT); Function of homologous gene experimentally demonstrated in an other organism; enzyme.
    
 0.953
korA
2-oxoacid:ferredoxin oxidoreductase, alpha subunit; Function of strongly homologous gene; enzyme.
  
 
 0.947
korB
2-oxoacid:ferredoxin oxidoreductase, beta subunit; Function of strongly homologous gene; enzyme.
     
 0.919
citA
Citrate synthase 2; Function of strongly homologous gene; enzyme; Belongs to the citrate synthase family.
  
 
 0.884
gltA
Citrate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the citrate synthase family.
  
 
 0.884
sucC
Succinyl-CoA ligase [ADP-forming] subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
  
  
 0.882
gcvP
Glycine cleavage system P-protein (glycine dehydrogenase); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.
   
  
 0.872
Your Current Organism:
Modestobacter marinus
NCBI taxonomy Id: 477641
Other names: CGMCC 4.5581, DSM 45201, M. marinus, Modestobacter marinus Xiao et al. 2011, Modestobacter sp. 42H12-1, strain 42H12-1
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