Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
pcaB3-carboxy-cis,cis-muconate cycloisomerase; Function of strongly homologous gene; enzyme. (443 aa)    
Predicted Functional Partners:
pcaC
4-carboxymuconolactone decarboxylase; Function of strongly homologous gene; enzyme.
 
 
 0.997
pcaG
Protocatechuate 3,4-dioxygenase alpha chain; Function of strongly homologous gene; enzyme.
 
 
 0.997
pcaH
Protocatechuate 3,4-dioxygenase beta chain; Function of strongly homologous gene; enzyme.
 
 
 0.996
purC
Phosphoribosylaminoimidazole-succinocarboxamide synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the SAICAR synthetase family.
  
 0.992
purE-2
Phosphoribosylaminoimidazole carboxylase catalytic subunit (AIR carboxylase) (AIRC); Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).
  
 0.981
pcaD
3-oxoadipate enol-lactonase; Function of strongly homologous gene; enzyme.
  
 0.979
purD
Phosphoribosylamine--glycine ligase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the GARS family.
  
 0.979
purA
Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
 
 0.979
purK
Phosphoribosylaminoimidazole carboxylase ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
  
 
 0.972
purM
Phosphoribosylformylglycinamidine cyclo-ligase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
  
 
 0.972
Your Current Organism:
Modestobacter marinus
NCBI taxonomy Id: 477641
Other names: CGMCC 4.5581, DSM 45201, M. marinus, Modestobacter marinus Xiao et al. 2011, Modestobacter sp. 42H12-1, strain 42H12-1
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