SIT34508.1 protein (Filimonas lacunae) - STRING interaction network

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second shell of interactors

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

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[Homology]

Score

SIT34508.1

Cysteine synthase A. (336 aa)

Predicted Functional Partners:

SIT34507.1

0.991

SIS62001.1

0.832

SIT34509.1

0.817

SIT34510.1

0.708

SIT34506.1

0.685

SIS79785.1

0.609

SIS62068.1

0.596

SIT34505.1

0.592

SIS95940.1

0.497

metZ

0.483

Your Current Organism:

Filimonas lacunae

NCBI taxonomy Id: 477680
Other names: Bacteroidetes bacterium YT0021, DSM 21054, F. lacunae, Filimonas lacunae Shiratori et al. 2009 emend. Leandro et al. 2013, NBRC 104114, strain YT0021, strain YT21

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SIS62001.1	SIS79785.1	SAMN05421788_101259	SAMN05421788_1011275	Serine O-acetyltransferase.	Cystathionine beta-lyase.	0.860
SIS62001.1	SIT34508.1	SAMN05421788_101259	SAMN05421788_1174	Serine O-acetyltransferase.	Cysteine synthase A.	0.832
SIS62001.1	metZ	SAMN05421788_101259	SAMN05421788_101235	Serine O-acetyltransferase.	O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide.	0.402
SIS62068.1	SIS79785.1	SAMN05421788_101264	SAMN05421788_1011275	Cystathionine beta-lyase.	Cystathionine beta-lyase.	0.902
SIS62068.1	SIT34508.1	SAMN05421788_101264	SAMN05421788_1174	Cystathionine beta-lyase.	Cysteine synthase A.	0.596
SIS62068.1	metZ	SAMN05421788_101264	SAMN05421788_101235	Cystathionine beta-lyase.	O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide.	0.914
SIS79785.1	SIS62001.1	SAMN05421788_1011275	SAMN05421788_101259	Cystathionine beta-lyase.	Serine O-acetyltransferase.	0.860
SIS79785.1	SIS62068.1	SAMN05421788_1011275	SAMN05421788_101264	Cystathionine beta-lyase.	Cystathionine beta-lyase.	0.902
SIS79785.1	SIT34508.1	SAMN05421788_1011275	SAMN05421788_1174	Cystathionine beta-lyase.	Cysteine synthase A.	0.609
SIS79785.1	metZ	SAMN05421788_1011275	SAMN05421788_101235	Cystathionine beta-lyase.	O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide.	0.827
SIS95940.1	SIT34508.1	SAMN05421788_102333	SAMN05421788_1174	Molybdopterin synthase sulfur carrier subunit.	Cysteine synthase A.	0.497
SIT34505.1	SIT34506.1	SAMN05421788_1171	SAMN05421788_1172	AMP-binding enzyme.	Amino acid adenylation domain-containing protein.	0.693
SIT34505.1	SIT34507.1	SAMN05421788_1171	SAMN05421788_1173	AMP-binding enzyme.	Ornithine cyclodeaminase.	0.676
SIT34505.1	SIT34508.1	SAMN05421788_1171	SAMN05421788_1174	AMP-binding enzyme.	Cysteine synthase A.	0.592
SIT34505.1	SIT34509.1	SAMN05421788_1171	SAMN05421788_1175	AMP-binding enzyme.	Diaminobutyrate-2-oxoglutarate transaminase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.584
SIT34505.1	SIT34510.1	SAMN05421788_1171	SAMN05421788_1176	AMP-binding enzyme.	Siderophore biosynthesis non-ribosomal peptide synthetase modules; Surfactin family lipopeptide synthetase A/fengycin family lipopeptide synthetase B/lichenysin synthetase A; Belongs to the ATP-dependent AMP-binding enzyme family.	0.640
SIT34506.1	SIT34505.1	SAMN05421788_1172	SAMN05421788_1171	Amino acid adenylation domain-containing protein.	AMP-binding enzyme.	0.693
SIT34506.1	SIT34507.1	SAMN05421788_1172	SAMN05421788_1173	Amino acid adenylation domain-containing protein.	Ornithine cyclodeaminase.	0.779
SIT34506.1	SIT34508.1	SAMN05421788_1172	SAMN05421788_1174	Amino acid adenylation domain-containing protein.	Cysteine synthase A.	0.685
SIT34506.1	SIT34509.1	SAMN05421788_1172	SAMN05421788_1175	Amino acid adenylation domain-containing protein.	Diaminobutyrate-2-oxoglutarate transaminase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.693

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

21

average node degree:

3.82

avg. local clustering coefficient:

0.904

expected number of edges:

11

PPI enrichment p-value:

0.00438

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0018106

Peptidyl-histidine phosphorylation

8 of 69

1.57

2.69

4.64e-09

GO:0000160

Phosphorelay signal transduction system

9 of 120

1.39

2.19

4.64e-09

GO:0050896

Response to stimulus

11 of 336

1.03

1.3

4.64e-09

GO:0050794

Regulation of cellular process

11 of 352

1.01

1.26

4.64e-09

GO:0006355

Regulation of transcription, DNA-templated

8 of 222

1.07

1.22

2.30e-06

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0043565

Sequence-specific DNA binding

7 of 50

1.66

2.88

5.80e-09

GO:0000155

Phosphorelay sensor kinase activity

8 of 73

1.55

2.63

4.72e-09

GO:0003700

DNA-binding transcription factor activity

7 of 93

1.39

1.96

2.24e-07

GO:0003677

DNA binding

8 of 281

0.96

1.0

1.05e-05

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009986

Cell surface

7 of 32

1.85

3.66

3.79e-10

GO:0016021

Integral component of membrane

10 of 699

0.67

0.59

4.59e-05

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3690

His Kinase A (phosphoacceptor) domain, and cheY-homologous receiver domain

10 of 46

1.85

4.83

3.36e-15

CL:3697

PAS domain, and cheY-homologous receiver domain

8 of 28

1.97

4.77

5.44e-13

CL:3691

PAS domain, and cheY-homologous receiver domain

9 of 41

1.85

4.58

5.96e-14

CL:3699

PAS domain, and cheY-homologous receiver domain

6 of 21

1.97

3.74

1.61e-09

CL:3702

PAS domain, and cheY-homologous receiver domain

5 of 16

2.01

3.26

6.33e-08

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map02020

Two-component system

11 of 403

0.95

1.13

5.70e-09

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0418

Kinase

9 of 127

1.36

2.18

1.35e-09

KW-0597

Phosphoprotein

6 of 74

1.42

1.79

4.45e-06

KW-0067

ATP-binding

7 of 215

1.02

1.03

4.39e-05

KW-0902

Two-component regulatory system

2 of 12

1.73

0.84

0.0222

KW-0175

Coiled coil

6 of 248

0.89

0.73

0.0014

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR004358

Signal transduction histidine kinase-related protein, C-terminal

9 of 44

1.82

4.18

1.25e-12

IPR003661

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain

9 of 51

1.76

3.9

2.08e-12

IPR005467

Histidine kinase domain

9 of 52

1.75

3.87

2.08e-12

IPR036097

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily

9 of 54

1.73

3.81

2.08e-12

IPR003594

Histidine kinase/HSP90-like ATPase

9 of 60

1.69

3.61

3.17e-12

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00388

His Kinase A (phosphoacceptor) domain

10 of 60

1.73

4.27

4.94e-15

SM00387

Histidine kinase-like ATPases

9 of 63

1.67

3.62

9.28e-13

SM00091

PAS domain

6 of 26

1.87

3.4

4.98e-09

SM00086

Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)

5 of 24

1.83

2.77

2.90e-07

SM00448

cheY-homologous receiver domain

6 of 68

1.46

2.03

5.81e-07

(more ...)

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