node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CDO86523.1 | CDO89736.1 | BN973_00867 | BN973_04116 | Acetolactate synthase; Belongs to the TPP enzyme family. | Oxidoreductase subunit beta. | 0.940 |
CDO86523.1 | CDO89737.1 | BN973_00867 | BN973_04117 | Acetolactate synthase; Belongs to the TPP enzyme family. | Pyruvate synthase. | 0.903 |
CDO86523.1 | ilvA | BN973_00867 | BN973_02773 | Acetolactate synthase; Belongs to the TPP enzyme family. | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.973 |
CDO86523.1 | ilvC | BN973_00867 | BN973_02139 | Acetolactate synthase; Belongs to the TPP enzyme family. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.992 |
CDO86523.1 | ilvH | BN973_00867 | BN973_02138 | Acetolactate synthase; Belongs to the TPP enzyme family. | Acetolactate synthase 3 regulatory subunit. | 0.998 |
CDO86523.1 | leuA_1 | BN973_00867 | BN973_00087 | Acetolactate synthase; Belongs to the TPP enzyme family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.928 |
CDO86523.1 | leuB | BN973_00867 | BN973_02142 | Acetolactate synthase; Belongs to the TPP enzyme family. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. | 0.943 |
CDO86523.1 | mez | BN973_00867 | BN973_03962 | Acetolactate synthase; Belongs to the TPP enzyme family. | [NAD]-dependent malate oxidoreductase. | 0.896 |
CDO86523.1 | mez_1 | BN973_00867 | BN973_04426 | Acetolactate synthase; Belongs to the TPP enzyme family. | [NAD] dependent malate oxidoreductase Mez. | 0.896 |
CDO86523.1 | pykA | BN973_00867 | BN973_02820 | Acetolactate synthase; Belongs to the TPP enzyme family. | Pyruvate kinase; Belongs to the pyruvate kinase family. | 0.897 |
CDO89736.1 | CDO86523.1 | BN973_04116 | BN973_00867 | Oxidoreductase subunit beta. | Acetolactate synthase; Belongs to the TPP enzyme family. | 0.940 |
CDO89736.1 | CDO89737.1 | BN973_04116 | BN973_04117 | Oxidoreductase subunit beta. | Pyruvate synthase. | 0.999 |
CDO89736.1 | ilvA | BN973_04116 | BN973_02773 | Oxidoreductase subunit beta. | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.782 |
CDO89736.1 | ilvH | BN973_04116 | BN973_02138 | Oxidoreductase subunit beta. | Acetolactate synthase 3 regulatory subunit. | 0.937 |
CDO89736.1 | leuA_1 | BN973_04116 | BN973_00087 | Oxidoreductase subunit beta. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.883 |
CDO89736.1 | leuB | BN973_04116 | BN973_02142 | Oxidoreductase subunit beta. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. | 0.755 |
CDO89736.1 | mez | BN973_04116 | BN973_03962 | Oxidoreductase subunit beta. | [NAD]-dependent malate oxidoreductase. | 0.888 |
CDO89736.1 | mez_1 | BN973_04116 | BN973_04426 | Oxidoreductase subunit beta. | [NAD] dependent malate oxidoreductase Mez. | 0.888 |
CDO89736.1 | pykA | BN973_04116 | BN973_02820 | Oxidoreductase subunit beta. | Pyruvate kinase; Belongs to the pyruvate kinase family. | 0.919 |
CDO89737.1 | CDO86523.1 | BN973_04117 | BN973_00867 | Pyruvate synthase. | Acetolactate synthase; Belongs to the TPP enzyme family. | 0.903 |