node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CDO90498.1 | metB | BN973_04893 | BN973_04891 | Cystathionine beta-synthase. | Cystathionine gamma-synthase. | 0.998 |
CDO90498.1 | metC | BN973_04893 | BN973_01592 | Cystathionine beta-synthase. | O-acetylhomoserine sulfhydrylase. | 0.933 |
CDO90498.1 | metE | BN973_04893 | BN973_04831 | Cystathionine beta-synthase. | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.909 |
CDO90498.1 | metH | BN973_04893 | BN973_03595 | Cystathionine beta-synthase. | B12-dependent methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.930 |
CDO90498.1 | metK | BN973_04893 | BN973_02623 | Cystathionine beta-synthase. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.415 |
CDO90498.1 | metZ | BN973_04893 | BN973_01042 | Cystathionine beta-synthase. | O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. | 0.989 |
CDO90498.1 | mmuM | BN973_04893 | BN973_04119 | Cystathionine beta-synthase. | Homocysteine methyltransferase. | 0.885 |
CDO90498.1 | sahH | BN973_04893 | BN973_01706 | Cystathionine beta-synthase. | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.957 |
CDO90498.1 | thrA | BN973_04893 | BN973_04336 | Cystathionine beta-synthase. | Homoserine dehydrogenase. | 0.912 |
CDO90498.1 | thrB | BN973_04893 | BN973_04334 | Cystathionine beta-synthase. | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. | 0.888 |
metB | CDO90498.1 | BN973_04891 | BN973_04893 | Cystathionine gamma-synthase. | Cystathionine beta-synthase. | 0.998 |
metB | metC | BN973_04891 | BN973_01592 | Cystathionine gamma-synthase. | O-acetylhomoserine sulfhydrylase. | 0.919 |
metB | metE | BN973_04891 | BN973_04831 | Cystathionine gamma-synthase. | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.962 |
metB | metH | BN973_04891 | BN973_03595 | Cystathionine gamma-synthase. | B12-dependent methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.976 |
metB | metK | BN973_04891 | BN973_02623 | Cystathionine gamma-synthase. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.888 |
metB | metZ | BN973_04891 | BN973_01042 | Cystathionine gamma-synthase. | O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. | 0.895 |
metB | mmuM | BN973_04891 | BN973_04119 | Cystathionine gamma-synthase. | Homocysteine methyltransferase. | 0.914 |
metB | sahH | BN973_04891 | BN973_01706 | Cystathionine gamma-synthase. | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.918 |
metB | thrA | BN973_04891 | BN973_04336 | Cystathionine gamma-synthase. | Homoserine dehydrogenase. | 0.949 |
metB | thrB | BN973_04891 | BN973_04334 | Cystathionine gamma-synthase. | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. | 0.895 |