KIR65658.1 protein (Micromonospora carbonacea)

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second shell of interactors

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Edges:

Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

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[Homology]

Score

KIR65658.1

GntR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (445 aa)

Predicted Functional Partners:

KIR65657.1

0.684

LeuE

0.574

KIR65659.1

0.559

KIR66708.1

0.415

KIR65661.1

0.412

Your Current Organism:

Micromonospora carbonacea

NCBI taxonomy Id: 47853
Other names: ATCC 27114, ATCC 27115, DSM 43168, DSM 43815, IFO 14107, IFO 14108, JCM 3139, M. carbonacea, Micromonospora carbonacea subsp. aurantiaca, Micromonospora carbonacea subsp. carbonacea, NBRC 14108, NRRL 2972

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KIR65657.1	KIR65658.1	TK50_09870	TK50_09875	Acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	GntR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.684
KIR65657.1	KIR65659.1	TK50_09870	TK50_09880	Acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	uracil-DNA glycosylase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.420
KIR65657.1	LeuE	TK50_09870	TK50_09865	Acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.824
KIR65658.1	KIR65657.1	TK50_09875	TK50_09870	GntR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	Acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.684
KIR65658.1	KIR65659.1	TK50_09875	TK50_09880	GntR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	uracil-DNA glycosylase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.559
KIR65658.1	KIR65661.1	TK50_09875	TK50_09890	GntR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.412
KIR65658.1	KIR66708.1	TK50_09875	TK50_04425	GntR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hemerythrin; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.415
KIR65658.1	LeuE	TK50_09875	TK50_09865	GntR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.574
KIR65659.1	KIR65657.1	TK50_09880	TK50_09870	uracil-DNA glycosylase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.420
KIR65659.1	KIR65658.1	TK50_09880	TK50_09875	uracil-DNA glycosylase; Derived by automated computational analysis using gene prediction method: Protein Homology.	GntR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.559
KIR65659.1	KIR65661.1	TK50_09880	TK50_09890	uracil-DNA glycosylase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.491
KIR65659.1	LeuE	TK50_09880	TK50_09865	uracil-DNA glycosylase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.437
KIR65661.1	KIR65658.1	TK50_09890	TK50_09875	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	GntR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.412
KIR65661.1	KIR65659.1	TK50_09890	TK50_09880	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	uracil-DNA glycosylase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.491
KIR66708.1	KIR65658.1	TK50_04425	TK50_09875	Hemerythrin; Derived by automated computational analysis using gene prediction method: Protein Homology.	GntR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.415
LeuE	KIR65657.1	TK50_09865	TK50_09870	Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.824
LeuE	KIR65658.1	TK50_09865	TK50_09875	Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	GntR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.574
LeuE	KIR65659.1	TK50_09865	TK50_09880	Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	uracil-DNA glycosylase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.437

Network Stats

number of nodes:

11

number of edges:

40

average node degree:

7.27

avg. local clustering coefficient:

0.869

expected number of edges:

13

PPI enrichment p-value:

1.41e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006506

GPI anchor biosynthetic process

4 of 30

2.59

3.1

1.48e-06

GO:0009398

FMN biosynthetic process

2 of 2

3.47

2.13

0.00015

GO:0090407

Organophosphate biosynthetic process

6 of 572

1.49

1.83

8.75e-06

GO:1901137

Carbohydrate derivative biosynthetic process

6 of 638

1.44

1.74

1.06e-05

GO:0019637

Organophosphate metabolic process

7 of 939

1.34

1.61

7.64e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008531

Riboflavin kinase activity

2 of 2

3.47

1.59

0.0014

GO:0003919

FMN adenylyltransferase activity

2 of 5

3.07

1.45

0.0024

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030176

Integral component of endoplasmic reticulum membrane

2 of 70

1.92

0.72

0.0441

GO:0005789

Endoplasmic reticulum membrane

4 of 653

1.25

0.61

0.0419

GO:0031984

Organelle subcompartment

5 of 1567

0.97

0.52

0.0419

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:12625

Glycosylphosphatidylinositol (GPI)-anchor biosynthesis

4 of 15

2.89

3.7

1.51e-07

CL:12628

Glycosylphosphatidylinositol (GPI)-anchor biosynthesis

3 of 10

2.94

2.71

1.12e-05

CL:9572

Purine nucleotide salvage, and Adenylate kinase activity

3 of 31

2.45

1.99

0.00019

CL:9944

Mixed, incl. Calcineurin-like phosphoesterase, and Nicotinamide nucleotide metabolic process

3 of 46

2.28

1.84

0.00032

CL:9958

Riboflavin kinase domain superfamily, and Nudix N-terminal

2 of 5

3.07

1.67

0.00098

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00563

Glycosylphosphatidylinositol (GPI)-anchor biosynthesis

4 of 29

2.6

3.87

4.55e-08

map00740

Riboflavin metabolism

3 of 79

2.04

1.86

0.00020

map01100

Metabolic pathways

9 of 6166

0.63

0.51

0.00067

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-163125

Post-translational modification: synthesis of GPI-anchored proteins

4 of 30

2.59

3.46

2.92e-07

MAP-196843

Vitamin B2 (riboflavin) metabolism

2 of 6

2.99

1.6

0.0013

MAP-162710

Synthesis of glycosylphosphatidylinositol (GPI)

2 of 19

2.49

1.2

0.0063

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0042765

GPI-anchor transamidase complex

2 of 6

2.99

1.33

0.0040

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR023198

Phosphoglycolate phosphatase-like, domain 2

4 of 13

2.95

3.79

1.10e-07

IPR023465

Riboflavin kinase domain superfamily

3 of 3

3.47

3.34

9.32e-07

IPR015865

Riboflavin kinase domain, bacterial/eukaryotic

3 of 3

3.47

3.34

9.32e-07

IPR006439

HAD hydrolase, subfamily IA

4 of 26

2.65

3.31

6.34e-07

IPR041492

Haloacid dehalogenase-like hydrolase

4 of 28

2.62

3.3

6.34e-07

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00904

Riboflavin kinase

2 of 2

3.47

1.94

0.00033

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