node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GcvT | KIR63255.1 | TK50_23305 | TK50_20615 | Glycine cleavage system protein T; Derived by automated computational analysis using gene prediction method: Protein Homology. | Serine hydroxymethyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.983 |
GcvT | LpdA | TK50_23305 | TK50_23290 | Glycine cleavage system protein T; Derived by automated computational analysis using gene prediction method: Protein Homology. | Dihydrolipoamide dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.994 |
GcvT | MetF | TK50_23305 | TK50_23705 | Glycine cleavage system protein T; Derived by automated computational analysis using gene prediction method: Protein Homology. | 5,10-methylenetetrahydrofolate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the methylenetetrahydrofolate reductase family. | 0.990 |
GcvT | MetH | TK50_23305 | TK50_29310 | Glycine cleavage system protein T; Derived by automated computational analysis using gene prediction method: Protein Homology. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.983 |
GcvT | folD | TK50_23305 | TK50_19525 | Glycine cleavage system protein T; Derived by automated computational analysis using gene prediction method: Protein Homology. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.979 |
GcvT | gcvH | TK50_23305 | TK50_31330 | Glycine cleavage system protein T; Derived by automated computational analysis using gene prediction method: Protein Homology. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.999 |
GcvT | gcvP | TK50_23305 | TK50_31375 | Glycine cleavage system protein T; Derived by automated computational analysis using gene prediction method: Protein Homology. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.999 |
GcvT | glyA | TK50_23305 | TK50_00390 | Glycine cleavage system protein T; Derived by automated computational analysis using gene prediction method: Protein Homology. | Serine hydroxymethyltransferase; Catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.973 |
GcvT | glyA-3 | TK50_23305 | TK50_29985 | Glycine cleavage system protein T; Derived by automated computational analysis using gene prediction method: Protein Homology. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.994 |
GcvT | metH | TK50_23305 | TK50_29695 | Glycine cleavage system protein T; Derived by automated computational analysis using gene prediction method: Protein Homology. | B12-dependent methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.983 |
KIR63255.1 | GcvT | TK50_20615 | TK50_23305 | Serine hydroxymethyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Glycine cleavage system protein T; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.983 |
KIR63255.1 | LpdA | TK50_20615 | TK50_23290 | Serine hydroxymethyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Dihydrolipoamide dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.462 |
KIR63255.1 | MetF | TK50_20615 | TK50_23705 | Serine hydroxymethyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 5,10-methylenetetrahydrofolate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the methylenetetrahydrofolate reductase family. | 0.731 |
KIR63255.1 | MetH | TK50_20615 | TK50_29310 | Serine hydroxymethyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.646 |
KIR63255.1 | folD | TK50_20615 | TK50_19525 | Serine hydroxymethyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.793 |
KIR63255.1 | gcvH | TK50_20615 | TK50_31330 | Serine hydroxymethyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.835 |
KIR63255.1 | gcvP | TK50_20615 | TK50_31375 | Serine hydroxymethyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.991 |
KIR63255.1 | metH | TK50_20615 | TK50_29695 | Serine hydroxymethyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | B12-dependent methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.646 |
LpdA | GcvT | TK50_23290 | TK50_23305 | Dihydrolipoamide dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Glycine cleavage system protein T; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.994 |
LpdA | KIR63255.1 | TK50_23290 | TK50_20615 | Dihydrolipoamide dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Serine hydroxymethyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.462 |