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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
uvrBExcinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] (702 aa)    
Predicted Functional Partners:
uvrA
Excinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.
 
 0.999
uvrC
Excinuclease ABC subunit C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
 
 0.999
SCL27311.1
Excinuclease ABC, A subunit.
 
 
 0.997
SCL28048.1
Excinuclease ABC, A subunit.
 
 
 0.996
SCL23316.1
DNA polymerase-3 subunit epsilon.
 
 
 0.992
SCL13661.1
DNA helicase-2 / ATP-dependent DNA helicase PcrA.
  
 
 0.974
SCL13400.1
ATP-dependent DNA helicase, Rep family.
 
 
 0.940
SCL15671.1
TIGR00375 family protein.
  
 
 0.904
SCL13430.1
DNA helicase-2 / ATP-dependent DNA helicase PcrA; Belongs to the helicase family. UvrD subfamily.
  
 
 0.897
SCL13432.1
Superfamily I DNA or RNA helicase; Belongs to the helicase family. UvrD subfamily.
  
 
 0.897
Your Current Organism:
Micromonospora inyonensis
NCBI taxonomy Id: 47866
Other names: ATCC 27600, DSM 46123, JCM 3188, M. inyonensis, Micromonospora inyoensis, Micromonospora inyonensis Kroppenstedt et al. 2005, NBRC 13156, NRRL 3292
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