SER04107.1 protein (Lewinella agarilytica) - STRING interaction network

Nodes:

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second shell of interactors

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

SER04107.1

Transporter family-2 protein. (148 aa)

Predicted Functional Partners:

pyrE

0.576

SEQ25349.1

0.572

pyrD

0.561

SER04127.1

0.556

SER04074.1

0.520

SER04159.1

0.470

SER04190.1

0.412

Your Current Organism:

Lewinella agarilytica

NCBI taxonomy Id: 478744
Other names: DSM 24740, JBRI 2009, JCM 14216, KCTC 12774, L. agarilytica, Lewinella agarilytica Lee 2007, strain SST-19

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SEQ25349.1	SER04107.1	SAMN05444359_10788	SAMN05444359_12244	Orotidine-5'-phosphate decarboxylase.	Transporter family-2 protein.	0.572
SEQ25349.1	pyrD	SAMN05444359_10788	SAMN05444359_11716	Orotidine-5'-phosphate decarboxylase.	Dihydroorotate oxidase A; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.	0.956
SEQ25349.1	pyrE	SAMN05444359_10788	SAMN05444359_102248	Orotidine-5'-phosphate decarboxylase.	Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).	0.949
SER04074.1	SER04107.1	SAMN05444359_12243	SAMN05444359_12244	Hypothetical protein.	Transporter family-2 protein.	0.520
SER04107.1	SEQ25349.1	SAMN05444359_12244	SAMN05444359_10788	Transporter family-2 protein.	Orotidine-5'-phosphate decarboxylase.	0.572
SER04107.1	SER04074.1	SAMN05444359_12244	SAMN05444359_12243	Transporter family-2 protein.	Hypothetical protein.	0.520
SER04107.1	SER04127.1	SAMN05444359_12244	SAMN05444359_12245	Transporter family-2 protein.	Hypothetical protein.	0.556
SER04107.1	SER04159.1	SAMN05444359_12244	SAMN05444359_12246	Transporter family-2 protein.	Carboxynorspermidine dehydrogenase.	0.470
SER04107.1	SER04190.1	SAMN05444359_12244	SAMN05444359_12247	Transporter family-2 protein.	NTE family protein.	0.412
SER04107.1	pyrD	SAMN05444359_12244	SAMN05444359_11716	Transporter family-2 protein.	Dihydroorotate oxidase A; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.	0.561
SER04107.1	pyrE	SAMN05444359_12244	SAMN05444359_102248	Transporter family-2 protein.	Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).	0.576
SER04127.1	SER04107.1	SAMN05444359_12245	SAMN05444359_12244	Hypothetical protein.	Transporter family-2 protein.	0.556
SER04127.1	SER04159.1	SAMN05444359_12245	SAMN05444359_12246	Hypothetical protein.	Carboxynorspermidine dehydrogenase.	0.642
SER04127.1	SER04190.1	SAMN05444359_12245	SAMN05444359_12247	Hypothetical protein.	NTE family protein.	0.556
SER04159.1	SER04107.1	SAMN05444359_12246	SAMN05444359_12244	Carboxynorspermidine dehydrogenase.	Transporter family-2 protein.	0.470
SER04159.1	SER04127.1	SAMN05444359_12246	SAMN05444359_12245	Carboxynorspermidine dehydrogenase.	Hypothetical protein.	0.642
SER04159.1	SER04190.1	SAMN05444359_12246	SAMN05444359_12247	Carboxynorspermidine dehydrogenase.	NTE family protein.	0.664
SER04190.1	SER04107.1	SAMN05444359_12247	SAMN05444359_12244	NTE family protein.	Transporter family-2 protein.	0.412
SER04190.1	SER04127.1	SAMN05444359_12247	SAMN05444359_12245	NTE family protein.	Hypothetical protein.	0.556
SER04190.1	SER04159.1	SAMN05444359_12247	SAMN05444359_12246	NTE family protein.	Carboxynorspermidine dehydrogenase.	0.664

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Network Stats

number of nodes:

11

number of edges:

38

average node degree:

6.91

avg. local clustering coefficient:

0.649

expected number of edges:

11

PPI enrichment p-value:

1.6e-10

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006412

Translation

10 of 116

1.35

2.24

2.26e-10

GO:0010467

Gene expression

11 of 203

1.15

1.66

2.26e-10

GO:0009059

Macromolecule biosynthetic process

11 of 227

1.1

1.54

2.26e-10

GO:0044271

Cellular nitrogen compound biosynthetic process

11 of 354

0.91

1.05

1.55e-08

GO:0044238

Primary metabolic process

11 of 1054

0.44

0.36

0.0010

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003735

Structural constituent of ribosome

10 of 57

1.66

3.72

1.68e-13

GO:0019843

rRNA binding

5 of 41

1.5

1.61

8.00e-05

GO:0003723

RNA binding

6 of 91

1.24

1.28

8.44e-05

GO:0003676

Nucleic acid binding

7 of 415

0.64

0.39

0.0358

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005840

Ribosome

10 of 60

1.64

3.71

5.03e-14

GO:0015935

Small ribosomal subunit

2 of 6

1.94

1.09

0.0077

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1083

Mixed, incl. Small ribosomal subunit, and Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like

6 of 10

2.19

4.53

1.70e-10

CL:1043

Structural constituent of ribosome

11 of 56

1.71

4.35

3.06e-16

CL:1044

Structural constituent of ribosome

8 of 44

1.68

3.38

3.99e-11

CL:1045

Structural constituent of ribosome

7 of 37

1.69

3.12

1.30e-09

CL:1132

rRNA-binding

3 of 11

1.85

1.62

0.00045

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03010

Ribosome

10 of 60

1.64

3.71

4.67e-14

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005840

Ribosome

9 of 48

1.69

3.62

3.59e-12

GOCC:0015935

Small ribosomal subunit

4 of 12

1.94

2.36

9.51e-06

GOCC:0022627

Cytosolic small ribosomal subunit

3 of 10

1.89

1.68

0.00036

GOCC:0043229

Intracellular organelle

10 of 311

0.92

1.04

1.79e-07

GOCC:0005622

Intracellular

11 of 1193

0.38

0.32

0.0018

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0689

Ribosomal protein

10 of 58

1.65

3.76

6.24e-14

KW-0699

rRNA-binding

5 of 38

1.54

1.82

1.79e-05

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