STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mdhMalate dehydrogenase (NAD); Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (342 aa)    
Predicted Functional Partners:
ACV06947.1
PFAM: Citrate synthase; TIGRFAM: citrate synthase I (hexameric type); Belongs to the citrate synthase family.
  
 0.995
fumC
Fumarase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
  
 0.983
ACV05159.1
PFAM: Malic enzyme, NAD binding domain; Malic enzyme, N-terminal domain.
  
 0.946
ACV06092.1
PFAM: Malic enzyme, N-terminal domain; Malic enzyme, NAD binding domain.
  
 0.946
ACV07099.1
PFAM: Aminotransferase class I and II.
  
 0.921
ACV07200.1
PFAM: Methylmalonyl-CoA mutase; B12 binding domain; TIGRFAM: methylmalonyl-CoA mutase C-terminal domain; methylmalonyl-CoA mutase N-terminal domain.
    
 0.874
ACV06847.1
2-oxoglutarate dehydrogenase E1 component; PFAM: Transketolase, pyrimidine binding domain; 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Dehydrogenase E1 component; TIGRFAM: 2-oxoglutarate dehydrogenase, E1 component.
 
 
 0.873
sucC
succinyl-CoA synthetase (ADP-forming) beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
  
 
 0.867
ACV06969.1
PFAM: Monomeric isocitrate dehydrogenase; TIGRFAM: isocitrate dehydrogenase, NADP-dependent, monomeric type; Belongs to the monomeric-type IDH family.
  
  
 0.859
argH
PFAM: Lyase; TIGRFAM: argininosuccinate lyase.
  
 0.851
Your Current Organism:
Kytococcus sedentarius
NCBI taxonomy Id: 478801
Other names: K. sedentarius DSM 20547, Kytococcus sedentarius DSM 20547, Kytococcus sedentarius str. DSM 20547, Kytococcus sedentarius strain DSM 20547
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.