AV274_6473 protein (Blastocystis sp. ATCC 50177Nand)

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second shell of interactors

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a 3D structure is known or predicted

Edges:

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

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[Homology]

Score

AV274_6473

E3 ubiquitin-protein ligase SHPRH. (1327 aa)

Predicted Functional Partners:

AV274_4960

0.954

AV274_2510

0.920

AV274_0800

0.880

AV274_6154

0.877

AV274_4353

0.861

AV274_4923

0.861

AV274_2907

0.861

AV274_3423

0.858

AV274_2174

0.858

AV274_1893

0.853

Your Current Organism:

Blastocystis sp. ATCC 50177Nand

NCBI taxonomy Id: 478820
Other names: B. sp. ATCC 50177/Nand II, Blastocystis sp. ATCC 50177, Blastocystis sp. ATCC 50177/Nand II, Blastocystis sp. Nand II, Blastocystis sp. NandII, Blastocystis sp. subtype 1 NandII

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AV274_0800	AV274_2510	A0A196SML5	A0A196SFF7	DNA-directed RNA polymerases I, II, and III subunit RPABC2-like protein.	Uncharacterized protein.	0.987
AV274_0800	AV274_2907	A0A196SML5	A0A196SEF0	DNA-directed RNA polymerases I, II, and III subunit RPABC2-like protein.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.440
AV274_0800	AV274_4353	A0A196SML5	A0A196SAA1	DNA-directed RNA polymerases I, II, and III subunit RPABC2-like protein.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.440
AV274_0800	AV274_4923	A0A196SML5	A0A196SAR5	DNA-directed RNA polymerases I, II, and III subunit RPABC2-like protein.	Proliferating cell nuclear antigen.	0.440
AV274_0800	AV274_6154	A0A196SML5	A0A196S732	DNA-directed RNA polymerases I, II, and III subunit RPABC2-like protein.	PHD-type domain-containing protein.	0.780
AV274_0800	AV274_6473	A0A196SML5	A0A196S3Y0	DNA-directed RNA polymerases I, II, and III subunit RPABC2-like protein.	E3 ubiquitin-protein ligase SHPRH.	0.880
AV274_1893	AV274_2174	A0A196SJK0	A0A196SGF4	Ubiquitin-like protein.	RuvB-like helicase.	0.410
AV274_1893	AV274_2907	A0A196SJK0	A0A196SEF0	Ubiquitin-like protein.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.980
AV274_1893	AV274_3423	A0A196SJK0	A0A196SG16	Ubiquitin-like protein.	RuvB-like helicase.	0.410
AV274_1893	AV274_4353	A0A196SJK0	A0A196SAA1	Ubiquitin-like protein.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.980
AV274_1893	AV274_4923	A0A196SJK0	A0A196SAR5	Ubiquitin-like protein.	Proliferating cell nuclear antigen.	0.980
AV274_1893	AV274_4960	A0A196SJK0	A0A196S8B1	Ubiquitin-like protein.	ATP-dependent DNA helicase MPH1.	0.761
AV274_1893	AV274_6473	A0A196SJK0	A0A196S3Y0	Ubiquitin-like protein.	E3 ubiquitin-protein ligase SHPRH.	0.853
AV274_2174	AV274_1893	A0A196SGF4	A0A196SJK0	RuvB-like helicase.	Ubiquitin-like protein.	0.410
AV274_2174	AV274_2510	A0A196SGF4	A0A196SFF7	RuvB-like helicase.	Uncharacterized protein.	0.556
AV274_2174	AV274_3423	A0A196SGF4	A0A196SG16	RuvB-like helicase.	RuvB-like helicase.	0.400
AV274_2174	AV274_6473	A0A196SGF4	A0A196S3Y0	RuvB-like helicase.	E3 ubiquitin-protein ligase SHPRH.	0.858
AV274_2510	AV274_0800	A0A196SFF7	A0A196SML5	Uncharacterized protein.	DNA-directed RNA polymerases I, II, and III subunit RPABC2-like protein.	0.987
AV274_2510	AV274_2174	A0A196SFF7	A0A196SGF4	Uncharacterized protein.	RuvB-like helicase.	0.556
AV274_2510	AV274_2907	A0A196SFF7	A0A196SEF0	Uncharacterized protein.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.722

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Network Stats

number of nodes:

11

number of edges:

38

average node degree:

6.91

avg. local clustering coefficient:

0.86

expected number of edges:

19

PPI enrichment p-value:

5.12e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030433

Ubiquitin-dependent ERAD pathway

6 of 49

2.45

4.92

1.52e-10

GO:0030968

Endoplasmic reticulum unfolded protein response

4 of 27

2.53

3.41

3.18e-07

GO:1904152

Regulation of retrograde protein transport, ER to cytosol

3 of 8

2.94

3.05

2.66e-06

GO:0090317

Negative regulation of intracellular protein transport

3 of 9

2.89

3.0

3.15e-06

GO:0019538

Protein metabolic process

7 of 2965

0.74

0.53

0.0061

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005047

Signal recognition particle binding

2 of 5

2.97

1.22

0.0064

GO:0051787

Misfolded protein binding

2 of 14

2.52

0.95

0.0182

GO:0061630

Ubiquitin protein ligase activity

3 of 182

1.58

0.72

0.0358

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0140534

Endoplasmic reticulum protein-containing complex

4 of 66

2.15

2.55

7.49e-06

GO:0000839

Hrd1p ubiquitin ligase ERAD-L complex

2 of 4

3.06

1.9

0.00037

GO:0005783

Endoplasmic reticulum

7 of 726

1.35

1.68

4.20e-06

GO:0000151

Ubiquitin ligase complex

4 of 217

1.63

1.52

0.00037

GO:0005788

Endoplasmic reticulum lumen

2 of 44

2.02

1.11

0.0076

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4403

Mixed, incl. ERAD pathway, and UBX domain

11 of 45

2.75

12.67

7.05e-27

CL:4405

ERAD pathway, and TRC8 N-terminal domain

8 of 22

2.92

9.79

1.51e-19

CL:4409

Mixed, incl. Sel1-like repeats., and Derlin

7 of 11

3.17

9.33

4.36e-18

CL:4413

Derlin, and Protein OS-9-like

4 of 5

3.27

4.91

1.16e-09

CL:4450

Mixed, incl. UBX domain, and Josephin domain DUBs

3 of 20

2.54

2.33

4.50e-05

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pdam04141

Protein processing in endoplasmic reticulum

4 of 83

2.05

2.55

5.23e-06

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-382556

ABC-family proteins mediated transport

8 of 171

2.03

4.93

8.53e-13

MAP-5358346

Hedgehog ligand biogenesis

6 of 66

2.32

4.83

9.72e-11

MAP-5358351

Signaling by Hedgehog

6 of 132

2.02

3.73

3.52e-09

MAP-532668

N-glycan trimming in the ER and Calnexin/Calreticulin cycle

4 of 41

2.35

3.19

5.71e-07

MAP-5689877

Josephin domain DUBs

3 of 10

2.84

3.01

2.92e-06

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005789

Endoplasmic reticulum membrane

6 of 159

1.94

3.33

2.04e-08

GOCC:0000836

Hrd1p ubiquitin ligase complex

3 of 9

2.89

3.01

3.06e-06

GOCC:0005783

Endoplasmic reticulum

7 of 321

1.7

2.86

2.04e-08

GOCC:0098796

Membrane protein complex

6 of 479

1.46

1.89

3.30e-06

GOCC:0012505

Endomembrane system

8 of 1207

1.18

1.46

1.12e-06

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF04511

Der1-like family

2 of 2

3.36

1.55

0.0016

PF07915

Glucosidase II beta subunit-like protein

2 of 4

3.06

1.49

0.0020

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR041569

AAA ATPase, AAA+ lid domain

3 of 21

2.52

1.78

0.00052

IPR003960

ATPase, AAA-type, conserved site

3 of 23

2.48

1.77

0.00052

IPR045149

Protein OS-9-like

2 of 2

3.36

1.57

0.0015

IPR012913

Protein OS9-like domain

2 of 2

3.36

1.57

0.0015

IPR007599

Derlin

2 of 2

3.36

1.57

0.0015

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00382

ATPases associated with a variety of cellular activities

3 of 155

1.65

0.82

0.0224

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