AV274_5786 protein (Blastocystis sp. ATCC 50177Nand)

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Cooccurrence

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[Homology]

Score

AV274_5786

Importin subunit alpha-2. (406 aa)

Predicted Functional Partners:

AV274_1811

0.959

AV274_0275

0.955

AV274_4935

0.885

AV274_5601

0.870

AV274_3422

0.867

AV274_5853

0.863

AV274_5198

0.863

AV274_4390

0.863

AV274_1046

0.858

AV274_6287

0.841

Your Current Organism:

Blastocystis sp. ATCC 50177Nand

NCBI taxonomy Id: 478820
Other names: B. sp. ATCC 50177/Nand II, Blastocystis sp. ATCC 50177, Blastocystis sp. ATCC 50177/Nand II, Blastocystis sp. Nand II, Blastocystis sp. NandII, Blastocystis sp. subtype 1 NandII

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AV274_0275	AV274_1046	A0A196SP31	A0A196SLX5	Importin subunit beta-1.	Sentrin-specific protease.	0.940
AV274_0275	AV274_1811	A0A196SP31	A0A196SHI4	Importin subunit beta-1.	CAS/CSE1 segregation protein.	0.718
AV274_0275	AV274_3422	A0A196SP31	A0A196SD27	Importin subunit beta-1.	MIF4G_like domain-containing protein.	0.938
AV274_0275	AV274_4390	A0A196SP31	A0A196SCP3	Importin subunit beta-1.	Nsp1p.	0.999
AV274_0275	AV274_4935	A0A196SP31	A0A196SB90	Importin subunit beta-1.	E3 SUMO-protein ligase RanBP2.	0.988
AV274_0275	AV274_5198	A0A196SP31	A0A196S7U8	Importin subunit beta-1.	Nsp1p.	0.999
AV274_0275	AV274_5601	A0A196SP31	A0A196S8P8	Importin subunit beta-1.	GTP-binding nuclear protein; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family.	0.999
AV274_0275	AV274_5786	A0A196SP31	A0A196S650	Importin subunit beta-1.	Importin subunit alpha-2.	0.955
AV274_0275	AV274_5853	A0A196SP31	A0A196S603	Importin subunit beta-1.	Nsp1p.	0.999
AV274_0275	AV274_6287	A0A196SP31	A0A196S4P5	Importin subunit beta-1.	Nuclear cap-binding protein subunit 2.	0.960
AV274_1046	AV274_0275	A0A196SLX5	A0A196SP31	Sentrin-specific protease.	Importin subunit beta-1.	0.940
AV274_1046	AV274_4390	A0A196SLX5	A0A196SCP3	Sentrin-specific protease.	Nsp1p.	0.914
AV274_1046	AV274_4935	A0A196SLX5	A0A196SB90	Sentrin-specific protease.	E3 SUMO-protein ligase RanBP2.	0.467
AV274_1046	AV274_5198	A0A196SLX5	A0A196S7U8	Sentrin-specific protease.	Nsp1p.	0.914
AV274_1046	AV274_5786	A0A196SLX5	A0A196S650	Sentrin-specific protease.	Importin subunit alpha-2.	0.858
AV274_1046	AV274_5853	A0A196SLX5	A0A196S603	Sentrin-specific protease.	Nsp1p.	0.914
AV274_1811	AV274_0275	A0A196SHI4	A0A196SP31	CAS/CSE1 segregation protein.	Importin subunit beta-1.	0.718
AV274_1811	AV274_4390	A0A196SHI4	A0A196SCP3	CAS/CSE1 segregation protein.	Nsp1p.	0.632
AV274_1811	AV274_4935	A0A196SHI4	A0A196SB90	CAS/CSE1 segregation protein.	E3 SUMO-protein ligase RanBP2.	0.743
AV274_1811	AV274_5198	A0A196SHI4	A0A196S7U8	CAS/CSE1 segregation protein.	Nsp1p.	0.632

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

54

average node degree:

9.82

avg. local clustering coefficient:

0.982

expected number of edges:

12

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009168

Purine ribonucleoside monophosphate biosynthetic process

10 of 16

2.96

12.45

5.84e-25

GO:0006189

De novo IMP biosynthetic process

8 of 8

3.17

10.77

6.83e-21

GO:0009152

Purine ribonucleotide biosynthetic process

10 of 75

2.29

8.19

3.43e-20

GO:0006144

Purine nucleobase metabolic process

5 of 19

2.59

5.02

1.82e-10

GO:0009113

Purine nucleobase biosynthetic process

4 of 9

2.81

4.39

6.59e-09

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016879

Ligase activity, forming carbon-nitrogen bonds

4 of 57

2.01

2.0

9.05e-05

GO:0016742

Hydroxymethyl-, formyl- and related transferase activity

2 of 7

2.62

1.24

0.0054

GO:0016763

Pentosyltransferase activity

2 of 23

2.11

0.96

0.0159

GO:0046872

Metal ion binding

7 of 1500

0.84

0.61

0.0054

GO:0032555

Purine ribonucleotide binding

6 of 1223

0.86

0.56

0.0138

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005737

Cytoplasm

11 of 4945

0.51

0.41

0.0018

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:12556

De novo IMP biosynthetic process

10 of 10

3.17

13.83

5.88e-27

CL:12554

Purine nucleoside monophosphate metabolic process, and Purine-containing compound catabolic process

11 of 27

2.78

12.84

4.74e-27

CL:12559

De novo IMP biosynthetic process

5 of 5

3.17

6.34

2.23e-12

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00230

Purine metabolism

10 of 118

2.1

6.81

1.07e-18

map00250

Alanine, aspartate and glutamate metabolism

3 of 44

2.0

1.91

0.00014

map01110

Biosynthesis of secondary metabolites

8 of 615

1.28

1.81

5.03e-08

map00670

One carbon pool by folate

2 of 24

2.09

1.26

0.0039

map01100

Metabolic pathways

10 of 2204

0.82

0.85

1.06e-06

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-73817

Purine ribonucleoside monophosphate biosynthesis

9 of 12

3.04

11.59

7.36e-23

MAP-8956320

Nucleotide biosynthesis

9 of 18

2.87

10.82

5.87e-22

MAP-15869

Metabolism of nucleotides

10 of 67

2.34

8.57

1.13e-20

MAP-1430728

Metabolism

10 of 1495

0.99

1.17

1.13e-07

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0658

Purine biosynthesis

3 of 5

2.95

3.0

3.22e-06

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02769

AIR synthase related protein, C-terminal domain

2 of 2

3.17

1.41

0.0029

PF00156

Phosphoribosyl transferase domain

2 of 4

2.87

1.34

0.0037

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036921

PurM-like, N-terminal domain superfamily

2 of 2

3.17

1.15

0.0085

IPR036676

PurM-like, C-terminal domain superfamily

2 of 2

3.17

1.15

0.0085

IPR010918

PurM-like, C-terminal domain

2 of 2

3.17

1.15

0.0085

IPR013815

ATP-grasp fold, subdomain 1

2 of 9

2.51

0.94

0.0194

IPR011054

Rudiment single hybrid motif

2 of 9

2.51

0.94

0.0194

(more ...)

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