AV274_4208 protein (Blastocystis sp. ATCC 50177Nand)

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query proteins and first shell of interactors

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second shell of interactors

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

AV274_4208

Protein kinase. (318 aa)

Predicted Functional Partners:

AV274_3378

0.958

AV274_4169

0.955

AV274_6125

0.890

AV274_1872

0.890

AV274_5447

0.888

AV274_2259

0.888

AV274_0408

0.864

AV274_6318

0.859

AV274_0301

0.857

AV274_6429

0.830

Your Current Organism:

Blastocystis sp. ATCC 50177Nand

NCBI taxonomy Id: 478820
Other names: B. sp. ATCC 50177/Nand II, Blastocystis sp. ATCC 50177, Blastocystis sp. ATCC 50177/Nand II, Blastocystis sp. Nand II, Blastocystis sp. NandII, Blastocystis sp. subtype 1 NandII

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AV274_0301	AV274_1872	A0A196SLN6	A0A196SKF0	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Calcium-binding protein 39-like protein.	0.841
AV274_0301	AV274_4208	A0A196SLN6	A0A196SAR2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Protein kinase.	0.857
AV274_0301	AV274_6125	A0A196SLN6	A0A196S871	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Mo25 family protein.	0.841
AV274_0408	AV274_1872	A0A196SNT4	A0A196SKF0	Protein serine/threonine kinase.	Calcium-binding protein 39-like protein.	0.841
AV274_0408	AV274_4208	A0A196SNT4	A0A196SAR2	Protein serine/threonine kinase.	Protein kinase.	0.864
AV274_0408	AV274_6125	A0A196SNT4	A0A196S871	Protein serine/threonine kinase.	Mo25 family protein.	0.841
AV274_1872	AV274_0301	A0A196SKF0	A0A196SLN6	Calcium-binding protein 39-like protein.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.841
AV274_1872	AV274_0408	A0A196SKF0	A0A196SNT4	Calcium-binding protein 39-like protein.	Protein serine/threonine kinase.	0.841
AV274_1872	AV274_4208	A0A196SKF0	A0A196SAR2	Calcium-binding protein 39-like protein.	Protein kinase.	0.890
AV274_1872	AV274_6318	A0A196SKF0	A0A196S7N2	Calcium-binding protein 39-like protein.	CBL-interacting serine/threonine-protein kinase 9.	0.841
AV274_1872	AV274_6429	A0A196SKF0	A0A196S7G2	Calcium-binding protein 39-like protein.	Serine/threonine protein kinase.	0.841
AV274_2259	AV274_3378	A0A196SJA3	A0A196SG21	Translocation protein SEC63.	Protein translocase SEC61 complex gamma subunit.	0.967
AV274_2259	AV274_4169	A0A196SJA3	A0A196SAQ6	Translocation protein SEC63.	Non-selective Cation Channel-2 (NSCC2) Family protein.	0.994
AV274_2259	AV274_4208	A0A196SJA3	A0A196SAR2	Translocation protein SEC63.	Protein kinase.	0.888
AV274_2259	AV274_5447	A0A196SJA3	A0A196S9S4	Translocation protein SEC63.	Translocation protein SEC63.	0.901
AV274_3378	AV274_2259	A0A196SG21	A0A196SJA3	Protein translocase SEC61 complex gamma subunit.	Translocation protein SEC63.	0.967
AV274_3378	AV274_4169	A0A196SG21	A0A196SAQ6	Protein translocase SEC61 complex gamma subunit.	Non-selective Cation Channel-2 (NSCC2) Family protein.	0.998
AV274_3378	AV274_4208	A0A196SG21	A0A196SAR2	Protein translocase SEC61 complex gamma subunit.	Protein kinase.	0.958
AV274_3378	AV274_5447	A0A196SG21	A0A196S9S4	Protein translocase SEC61 complex gamma subunit.	Translocation protein SEC63.	0.967
AV274_4169	AV274_2259	A0A196SAQ6	A0A196SJA3	Non-selective Cation Channel-2 (NSCC2) Family protein.	Translocation protein SEC63.	0.994

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

39

average node degree:

7.09

avg. local clustering coefficient:

0.855

expected number of edges:

11

PPI enrichment p-value:

2.85e-11

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009156

Ribonucleoside monophosphate biosynthetic process

7 of 49

1.92

3.85

3.20e-10

GO:0072522

Purine-containing compound biosynthetic process

7 of 58

1.84

3.61

5.30e-10

GO:0009260

Ribonucleotide biosynthetic process

7 of 58

1.84

3.61

5.30e-10

GO:0009168

Purine ribonucleoside monophosphate biosynthetic process

6 of 38

1.96

3.61

3.94e-09

GO:0046112

Nucleobase biosynthetic process

4 of 10

2.37

3.38

2.42e-07

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004044

Amidophosphoribosyltransferase activity

2 of 2

2.76

1.18

0.0073

GO:0016814

Hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines

2 of 10

2.06

0.73

0.0441

GO:0016742

Hydroxymethyl-, formyl- and related transferase activity

2 of 9

2.11

0.73

0.0441

GO:0046872

Metal ion binding

6 of 627

0.74

0.42

0.0441

GO:0003824

Catalytic activity

11 of 2064

0.49

0.38

0.0038

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:5740

Purine ribonucleoside monophosphate biosynthesis

5 of 11

2.42

4.14

6.73e-09

CL:5735

Nucleotide biosynthesis

6 of 30

2.06

3.77

4.39e-09

CL:5744

Purine nucleobase metabolic process, and Class II PurE

4 of 5

2.67

3.77

7.99e-08

CL:5573

Mixed, incl. Metabolism of nucleotides, and Cellular modified amino acid metabolic process

10 of 149

1.59

3.35

6.95e-13

CL:5581

Nucleoside monophosphate phosphorylation, and Drug ADME

4 of 15

2.19

2.85

1.90e-06

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00230

Purine metabolism

8 of 97

1.68

3.33

7.55e-11

map00250

Alanine, aspartate and glutamate metabolism

4 of 25

1.97

2.52

4.31e-06

map00670

One carbon pool by folate

2 of 18

1.81

0.94

0.0147

map01100

Metabolic pathways

10 of 959

0.78

0.77

3.44e-06

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-15869

Metabolism of nucleotides

9 of 65

1.9

4.75

8.61e-14

MAP-8956320

Nucleotide biosynthesis

7 of 38

2.03

4.34

5.98e-11

MAP-73817

Purine ribonucleoside monophosphate biosynthesis

6 of 36

1.99

3.59

5.86e-09

MAP-1430728

Metabolism

10 of 631

0.96

1.11

1.70e-07

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005737

Cytoplasm

10 of 1726

0.53

0.38

0.0104

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0658

Purine biosynthesis

4 of 6

2.59

3.56

1.82e-07

KW-0460

Magnesium

4 of 45

1.71

1.8

8.87e-05

KW-0630

Potassium

2 of 6

2.29

1.25

0.0046

KW-0963

Cytoplasm

3 of 105

1.22

0.68

0.0257

KW-0560

Oxidoreductase

2 of 32

1.56

0.67

0.0448

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF13522

Glutamine amidotransferase domain

2 of 2

2.76

1.04

0.0130

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR017932

Glutamine amidotransferase type 2 domain

2 of 2

2.76

0.77

0.0400

IPR005854

Amidophosphoribosyltransferase

2 of 2

2.76

0.77

0.0400

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