STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AV274_3955Queuine tRNA-ribosyltransferase catalytic subunit 1; Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, formi [...] (405 aa)    
Predicted Functional Partners:
AV274_3885
Queuine tRNA-ribosyltransferase domain-containing protein.
  
0.999
AV274_0639
Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family.
 
 
  0.975
AV274_5992
Thymidylate Kinase.
  
 
 0.819
AV274_0895
Deoxycytidylate deaminase.
    
  0.764
AV274_4394
Uncharacterized protein.
    
  0.743
AV274_4198
Uncharacterized protein.
    
  0.743
AV274_6396
dUTP pyrophosphatase.
  
 
  0.717
AV274_2524
Mitochondrial coenzyme A transporter; Belongs to the mitochondrial carrier (TC 2.A.29) family.
  
 
  0.717
AV274_5945
C-1-tetrahydrofolate synthase.
  
 
 0.670
AV274_3209
Methylenetetrahydrofolate dehydrogenase (NADP+) /methenyltetrahydrofolate cyclohydrolase.
  
 
 0.670
Your Current Organism:
Blastocystis sp. ATCC 50177Nand
NCBI taxonomy Id: 478820
Other names: B. sp. ATCC 50177/Nand II, Blastocystis sp. ATCC 50177, Blastocystis sp. ATCC 50177/Nand II, Blastocystis sp. Nand II, Blastocystis sp. NandII, Blastocystis sp. subtype 1 NandII
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