AV274_3313 protein (Blastocystis sp. ATCC 50177Nand)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

AV274_3313

50S ribosomal protein L11; Belongs to the universal ribosomal protein uL11 family. (152 aa)

Predicted Functional Partners:

AV274_5596

0.999

AV274_4131

0.999

AV274_3626

0.999

AV274_3526

0.999

AV274_2234

0.999

AV274_2663

0.999

AV274_1600

0.999

AV274_2130

0.999

AV274_2100

0.999

AV274_1607

0.999

Your Current Organism:

Blastocystis sp. ATCC 50177Nand

NCBI taxonomy Id: 478820
Other names: B. sp. ATCC 50177/Nand II, Blastocystis sp. ATCC 50177, Blastocystis sp. ATCC 50177/Nand II, Blastocystis sp. Nand II, Blastocystis sp. NandII, Blastocystis sp. subtype 1 NandII

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... functional annotations:

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AV274_1600	AV274_1607	A0A196SI34	A0A196SK43	LSU ribosomal protein L20P; Belongs to the bacterial ribosomal protein bL20 family.	Ribosomal protein L22; Belongs to the universal ribosomal protein uL22 family.	0.999
AV274_1600	AV274_2100	A0A196SI34	A0A196SJQ4	LSU ribosomal protein L20P; Belongs to the bacterial ribosomal protein bL20 family.	30S ribosomal protein S9; Belongs to the universal ribosomal protein uS9 family.	0.999
AV274_1600	AV274_2130	A0A196SI34	A0A196SJ30	LSU ribosomal protein L20P; Belongs to the bacterial ribosomal protein bL20 family.	50S ribosomal protein L13; Belongs to the universal ribosomal protein uL13 family.	0.999
AV274_1600	AV274_2234	A0A196SI34	A0A196SGA8	LSU ribosomal protein L20P; Belongs to the bacterial ribosomal protein bL20 family.	30S ribosomal protein S5.	0.999
AV274_1600	AV274_2663	A0A196SI34	A0A196SI08	LSU ribosomal protein L20P; Belongs to the bacterial ribosomal protein bL20 family.	50S ribosomal protein L15.	0.999
AV274_1600	AV274_3313	A0A196SI34	A0A196SF66	LSU ribosomal protein L20P; Belongs to the bacterial ribosomal protein bL20 family.	50S ribosomal protein L11; Belongs to the universal ribosomal protein uL11 family.	0.999
AV274_1600	AV274_3526	A0A196SI34	A0A196SFA0	LSU ribosomal protein L20P; Belongs to the bacterial ribosomal protein bL20 family.	Uncharacterized protein.	0.999
AV274_1600	AV274_3626	A0A196SI34	A0A196SCE4	LSU ribosomal protein L20P; Belongs to the bacterial ribosomal protein bL20 family.	37S ribosomal protein MRPS17.	0.991
AV274_1600	AV274_4131	A0A196SI34	A0A196SB09	LSU ribosomal protein L20P; Belongs to the bacterial ribosomal protein bL20 family.	Uncharacterized protein.	0.996
AV274_1600	AV274_5596	A0A196SI34	A0A196S8P3	LSU ribosomal protein L20P; Belongs to the bacterial ribosomal protein bL20 family.	LSU ribosomal protein L19P.	0.999
AV274_1607	AV274_1600	A0A196SK43	A0A196SI34	Ribosomal protein L22; Belongs to the universal ribosomal protein uL22 family.	LSU ribosomal protein L20P; Belongs to the bacterial ribosomal protein bL20 family.	0.999
AV274_1607	AV274_2100	A0A196SK43	A0A196SJQ4	Ribosomal protein L22; Belongs to the universal ribosomal protein uL22 family.	30S ribosomal protein S9; Belongs to the universal ribosomal protein uS9 family.	0.999
AV274_1607	AV274_2130	A0A196SK43	A0A196SJ30	Ribosomal protein L22; Belongs to the universal ribosomal protein uL22 family.	50S ribosomal protein L13; Belongs to the universal ribosomal protein uL13 family.	0.999
AV274_1607	AV274_2234	A0A196SK43	A0A196SGA8	Ribosomal protein L22; Belongs to the universal ribosomal protein uL22 family.	30S ribosomal protein S5.	0.999
AV274_1607	AV274_2663	A0A196SK43	A0A196SI08	Ribosomal protein L22; Belongs to the universal ribosomal protein uL22 family.	50S ribosomal protein L15.	0.999
AV274_1607	AV274_3313	A0A196SK43	A0A196SF66	Ribosomal protein L22; Belongs to the universal ribosomal protein uL22 family.	50S ribosomal protein L11; Belongs to the universal ribosomal protein uL11 family.	0.999
AV274_1607	AV274_3526	A0A196SK43	A0A196SFA0	Ribosomal protein L22; Belongs to the universal ribosomal protein uL22 family.	Uncharacterized protein.	0.999
AV274_1607	AV274_3626	A0A196SK43	A0A196SCE4	Ribosomal protein L22; Belongs to the universal ribosomal protein uL22 family.	37S ribosomal protein MRPS17.	0.998
AV274_1607	AV274_4131	A0A196SK43	A0A196SB09	Ribosomal protein L22; Belongs to the universal ribosomal protein uL22 family.	Uncharacterized protein.	0.997
AV274_1607	AV274_5596	A0A196SK43	A0A196S8P3	Ribosomal protein L22; Belongs to the universal ribosomal protein uL22 family.	LSU ribosomal protein L19P.	0.999

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Network Stats

number of nodes:

11

number of edges:

34

average node degree:

6.18

avg. local clustering coefficient:

0.72

expected number of edges:

15

PPI enrichment p-value:

2.66e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006094

Gluconeogenesis

3 of 29

2.38

2.19

7.07e-05

GO:0044283

Small molecule biosynthetic process

8 of 672

1.44

2.18

5.43e-08

GO:1901607

Alpha-amino acid biosynthetic process

5 of 201

1.76

2.17

1.04e-05

GO:0006096

Glycolytic process

4 of 108

1.94

2.03

6.07e-05

GO:0019284

L-methionine salvage from S-adenosylmethionine

2 of 3

3.19

2.02

0.00023

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016860

Intramolecular oxidoreductase activity

5 of 69

2.23

3.34

1.72e-07

GO:0004347

glucose-6-phosphate isomerase activity

3 of 3

3.37

3.26

1.28e-06

GO:0046570

Methylthioribulose 1-phosphate dehydratase activity

2 of 2

3.37

1.86

0.00044

GO:0043874

Acireductone synthase activity

2 of 2

3.37

1.86

0.00044

GO:0043716

2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase activity

2 of 2

3.37

1.86

0.00044

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:13634

L-serine biosynthetic process

3 of 11

2.8

2.33

5.40e-05

CL:13538

Mixed, incl. One carbon pool by folate, and De novo IMP biosynthetic process

4 of 59

2.2

2.19

5.40e-05

CL:14077

L-methionine salvage from S-adenosylmethionine, and S-methyl-5-thioribose kinase activity

2 of 5

2.97

1.3

0.0044

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pda00030

Pentose phosphate pathway

2 of 70

1.82

0.76

0.0346

pda01200

Carbon metabolism

3 of 304

1.36

0.67

0.0346

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-70171

Glycolysis

4 of 86

2.04

2.17

3.83e-05

MAP-70326

Glucose metabolism

4 of 132

1.85

1.88

0.00010

MAP-70263

Gluconeogenesis

3 of 93

1.88

1.32

0.0023

MAP-977347

Serine biosynthesis

2 of 16

2.46

1.29

0.0043

MAP-5628897

TP53 Regulates Metabolic Genes

3 of 144

1.69

1.14

0.0043

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0312

Gluconeogenesis

2 of 2

3.37

1.94

0.00032

KW-0324

Glycolysis

2 of 47

2.0

0.8

0.0309

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00342

Phosphoglucose isomerase

2 of 2

3.37

1.48

0.0022

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