AV274_2473 protein (Blastocystis sp. ATCC 50177Nand)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

AV274_2473

Uncharacterized protein; Belongs to the heat shock protein 70 family. (674 aa)

Predicted Functional Partners:

AV274_2091

0.889

AV274_0340

0.889

AV274_1374

0.887

AV274_5089

0.883

mge1

0.879

AV274_5744

0.872

AV274_5851

0.852

AV274_4575

0.831

AV274_4492

0.831

AV274_3551

0.830

Your Current Organism:

Blastocystis sp. ATCC 50177Nand

NCBI taxonomy Id: 478820
Other names: B. sp. ATCC 50177/Nand II, Blastocystis sp. ATCC 50177, Blastocystis sp. ATCC 50177/Nand II, Blastocystis sp. Nand II, Blastocystis sp. NandII, Blastocystis sp. subtype 1 NandII

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AV274_0340	AV274_2091	A0A196SQ11	A0A196SGG5	Ankyrin repeat family protein.	Ankyrin repeat family protein.	0.959
AV274_0340	AV274_2473	A0A196SQ11	A0A196SFH5	Ankyrin repeat family protein.	Uncharacterized protein; Belongs to the heat shock protein 70 family.	0.889
AV274_0340	AV274_3551	A0A196SQ11	A0A196SEU6	Ankyrin repeat family protein.	Chaperone protein dnaJ.	0.892
AV274_0340	AV274_4492	A0A196SQ11	A0A196SCG6	Ankyrin repeat family protein.	Chaperonin CPN60-1, mitochondrial; Belongs to the chaperonin (HSP60) family.	0.592
AV274_0340	AV274_4575	A0A196SQ11	A0A196S9H0	Ankyrin repeat family protein.	Chaperonin CPN60; Belongs to the chaperonin (HSP60) family.	0.592
AV274_0340	AV274_5089	A0A196SQ11	A0A196S885	Ankyrin repeat family protein.	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase.	0.877
AV274_0340	AV274_5744	A0A196SQ11	A0A196S914	Ankyrin repeat family protein.	Thioredoxin.	0.855
AV274_1374	AV274_2473	A0A196SIR6	A0A196SFH5	Mitochondrial Protein Translocase (MPT) Family Tim44.	Uncharacterized protein; Belongs to the heat shock protein 70 family.	0.887
AV274_1374	AV274_3551	A0A196SIR6	A0A196SEU6	Mitochondrial Protein Translocase (MPT) Family Tim44.	Chaperone protein dnaJ.	0.546
AV274_1374	AV274_4492	A0A196SIR6	A0A196SCG6	Mitochondrial Protein Translocase (MPT) Family Tim44.	Chaperonin CPN60-1, mitochondrial; Belongs to the chaperonin (HSP60) family.	0.751
AV274_1374	AV274_4575	A0A196SIR6	A0A196S9H0	Mitochondrial Protein Translocase (MPT) Family Tim44.	Chaperonin CPN60; Belongs to the chaperonin (HSP60) family.	0.751
AV274_1374	AV274_5851	A0A196SIR6	A0A196S802	Mitochondrial Protein Translocase (MPT) Family Tim44.	Co-chaperone Hsc20 family protein.	0.444
AV274_1374	mge1	A0A196SIR6	I3WER8	Mitochondrial Protein Translocase (MPT) Family Tim44.	GrpE; Belongs to the GrpE family.	0.993
AV274_2091	AV274_0340	A0A196SGG5	A0A196SQ11	Ankyrin repeat family protein.	Ankyrin repeat family protein.	0.959
AV274_2091	AV274_2473	A0A196SGG5	A0A196SFH5	Ankyrin repeat family protein.	Uncharacterized protein; Belongs to the heat shock protein 70 family.	0.889
AV274_2091	AV274_3551	A0A196SGG5	A0A196SEU6	Ankyrin repeat family protein.	Chaperone protein dnaJ.	0.892
AV274_2091	AV274_4492	A0A196SGG5	A0A196SCG6	Ankyrin repeat family protein.	Chaperonin CPN60-1, mitochondrial; Belongs to the chaperonin (HSP60) family.	0.592
AV274_2091	AV274_4575	A0A196SGG5	A0A196S9H0	Ankyrin repeat family protein.	Chaperonin CPN60; Belongs to the chaperonin (HSP60) family.	0.592
AV274_2091	AV274_5089	A0A196SGG5	A0A196S885	Ankyrin repeat family protein.	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase.	0.877
AV274_2091	AV274_5744	A0A196SGG5	A0A196S914	Ankyrin repeat family protein.	Thioredoxin.	0.855

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

41

average node degree:

7.45

avg. local clustering coefficient:

0.909

expected number of edges:

26

PPI enrichment p-value:

0.00345

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006091

Generation of precursor metabolites and energy

6 of 126

1.06

0.76

0.0060

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0051536

Iron-sulfur cluster binding

6 of 75

1.28

1.27

0.00018

GO:0051539

4 iron, 4 sulfur cluster binding

4 of 37

1.41

1.06

0.0032

GO:0005506

Iron ion binding

3 of 24

1.47

0.81

0.0188

GO:0016491

Oxidoreductase activity

7 of 244

0.84

0.63

0.0032

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:471

Tricarboxylic acid cycle, and 4Fe-4S binding domain

5 of 11

2.04

3.17

1.37e-07

CL:467

Mixed, incl. Citrate cycle (TCA cycle), and acetyl-CoA metabolic process

7 of 40

1.62

2.72

1.33e-08

CL:468

Citrate cycle (TCA cycle), and Alpha-helical ferredoxin

6 of 28

1.71

2.69

1.07e-07

CL:462

Mixed, incl. Oxidative phosphorylation, and Carbon metabolism

10 of 118

1.31

2.09

3.19e-10

CL:473

Tricarboxylic acid cycle

2 of 5

1.98

0.94

0.0161

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00620

Pyruvate metabolism

4 of 32

1.47

1.26

0.0010

map00020

Citrate cycle (TCA cycle)

3 of 18

1.6

1.23

0.0020

map01200

Carbon metabolism

5 of 76

1.2

1.03

0.0010

map00650

Butanoate metabolism

2 of 10

1.68

0.89

0.0166

map00190

Oxidative phosphorylation

4 of 70

1.14

0.86

0.0037

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0045272

Plasma membrane respiratory chain complex I

3 of 4

2.25

1.83

0.00033

GOCC:0098803

Respiratory chain complex

4 of 19

1.7

1.58

0.00033

GOCC:1990204

Oxidoreductase complex

4 of 33

1.46

1.28

0.00081

GOCC:1902494

Catalytic complex

5 of 150

0.9

0.64

0.0068

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0249

Electron transport

3 of 15

1.68

1.01

0.0087

KW-0816

Tricarboxylic acid cycle

2 of 7

1.83

0.82

0.0257

KW-0004

4Fe-4S

3 of 29

1.39

0.73

0.0257

KW-0560

Oxidoreductase

4 of 86

1.05

0.6

0.0257

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00037

4Fe-4S binding domain

5 of 6

2.3

3.53

8.60e-08

PF01515

Phosphate acetyl/butaryl transferase

2 of 2

2.38

0.92

0.0204

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR017900

4Fe-4S ferredoxin, iron-sulphur binding, conserved site

6 of 12

2.08

3.54

2.05e-08

IPR017896

4Fe-4S ferredoxin-type, iron-sulphur binding domain

6 of 16

1.95

3.25

4.08e-08

IPR042113

Phosphate acetyltransferase, domain 1

2 of 2

2.38

0.79

0.0356

IPR042112

Phosphate acetyltransferase, domain 2

2 of 2

2.38

0.79

0.0356

IPR002505

Phosphate acetyl/butaryl transferase

2 of 2

2.38

0.79

0.0356

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (14%) [HD]

Permalink

Network

Neighborhood

Experiments

Cooccurrence

Databases

Coexpression

Textmining

Fusion

© STRING Consortium 2024

Credits

Access

Info

About