AV274_2298 protein (Blastocystis sp. ATCC 50177Nand)

Nodes:

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

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[Homology]

Score

AV274_2298

Trans-sialidase. (1461 aa)

Predicted Functional Partners:

AV274_4225

0.943

AV274_4960

0.920

AV274_2112

0.920

AV274_4167

0.892

AV274_6078

0.889

AV274_0144

0.887

AV274_2328

0.868

AV274_1537

0.868

AV274_6350

0.867

AV274_1406

0.867

Your Current Organism:

Blastocystis sp. ATCC 50177Nand

NCBI taxonomy Id: 478820
Other names: B. sp. ATCC 50177/Nand II, Blastocystis sp. ATCC 50177, Blastocystis sp. ATCC 50177/Nand II, Blastocystis sp. Nand II, Blastocystis sp. NandII, Blastocystis sp. subtype 1 NandII

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AV274_0144	AV274_1406	A0A196SQT1	A0A196SII8	MUS81, Subunit of structure-specific Mms4p-Mus81p endonuclease.	DNA polymerase.	0.863
AV274_0144	AV274_2298	A0A196SQT1	A0A196SIH4	MUS81, Subunit of structure-specific Mms4p-Mus81p endonuclease.	Trans-sialidase.	0.887
AV274_0144	AV274_4960	A0A196SQT1	A0A196S8B1	MUS81, Subunit of structure-specific Mms4p-Mus81p endonuclease.	ATP-dependent DNA helicase MPH1.	0.999
AV274_0144	AV274_6350	A0A196SQT1	A0A196S6E5	MUS81, Subunit of structure-specific Mms4p-Mus81p endonuclease.	DNA polymerase.	0.863
AV274_1406	AV274_0144	A0A196SII8	A0A196SQT1	DNA polymerase.	MUS81, Subunit of structure-specific Mms4p-Mus81p endonuclease.	0.863
AV274_1406	AV274_2298	A0A196SII8	A0A196SIH4	DNA polymerase.	Trans-sialidase.	0.867
AV274_1406	AV274_4167	A0A196SII8	A0A196SCQ9	DNA polymerase.	Transmembrane protein.	0.493
AV274_1406	AV274_4225	A0A196SII8	A0A196SD40	DNA polymerase.	DNA polymerase delta subunit 2.	0.996
AV274_1406	AV274_4960	A0A196SII8	A0A196S8B1	DNA polymerase.	ATP-dependent DNA helicase MPH1.	0.961
AV274_1537	AV274_2112	A0A196SK74	A0A196SIN4	Small nuclear ribonucleoprotein Sm D2.	Small nuclear ribonucleoprotein Sm D1; Essential for pre-mRNA splicing. Implicated in the formation of stable, biologically active snRNP structures. Belongs to the snRNP core protein family.	0.998
AV274_1537	AV274_2298	A0A196SK74	A0A196SIH4	Small nuclear ribonucleoprotein Sm D2.	Trans-sialidase.	0.868
AV274_1537	AV274_6078	A0A196SK74	A0A196S5A3	Small nuclear ribonucleoprotein Sm D2.	Small nuclear ribonucleoprotein E; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. Belongs to the snRNP Sm proteins family.	0.998
AV274_2112	AV274_1537	A0A196SIN4	A0A196SK74	Small nuclear ribonucleoprotein Sm D1; Essential for pre-mRNA splicing. Implicated in the formation of stable, biologically active snRNP structures. Belongs to the snRNP core protein family.	Small nuclear ribonucleoprotein Sm D2.	0.998
AV274_2112	AV274_2298	A0A196SIN4	A0A196SIH4	Small nuclear ribonucleoprotein Sm D1; Essential for pre-mRNA splicing. Implicated in the formation of stable, biologically active snRNP structures. Belongs to the snRNP core protein family.	Trans-sialidase.	0.920
AV274_2112	AV274_2328	A0A196SIN4	A0A196SIK5	Small nuclear ribonucleoprotein Sm D1; Essential for pre-mRNA splicing. Implicated in the formation of stable, biologically active snRNP structures. Belongs to the snRNP core protein family.	Small nuclear ribonucleoprotein Sm D2.	0.998
AV274_2112	AV274_6078	A0A196SIN4	A0A196S5A3	Small nuclear ribonucleoprotein Sm D1; Essential for pre-mRNA splicing. Implicated in the formation of stable, biologically active snRNP structures. Belongs to the snRNP core protein family.	Small nuclear ribonucleoprotein E; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. Belongs to the snRNP Sm proteins family.	0.999
AV274_2298	AV274_0144	A0A196SIH4	A0A196SQT1	Trans-sialidase.	MUS81, Subunit of structure-specific Mms4p-Mus81p endonuclease.	0.887
AV274_2298	AV274_1406	A0A196SIH4	A0A196SII8	Trans-sialidase.	DNA polymerase.	0.867
AV274_2298	AV274_1537	A0A196SIH4	A0A196SK74	Trans-sialidase.	Small nuclear ribonucleoprotein Sm D2.	0.868
AV274_2298	AV274_2112	A0A196SIH4	A0A196SIN4	Trans-sialidase.	Small nuclear ribonucleoprotein Sm D1; Essential for pre-mRNA splicing. Implicated in the formation of stable, biologically active snRNP structures. Belongs to the snRNP core protein family.	0.920

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Network Stats

number of nodes:

7

number of edges:

16

average node degree:

4.57

avg. local clustering coefficient:

0.952

expected number of edges:

7

PPI enrichment p-value:

0.0014

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006811

Ion transport

9 of 154

1.4

2.23

3.80e-09

GO:0034220

Ion transmembrane transport

6 of 111

1.36

1.58

1.89e-05

GO:0098655

Cation transmembrane transport

4 of 83

1.31

0.92

0.0059

GO:0042773

ATP synthesis coupled electron transport

2 of 10

1.93

0.71

0.0461

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015297

Antiporter activity

7 of 40

1.87

3.56

1.41e-09

GO:0022804

Active transmembrane transporter activity

9 of 171

1.35

2.13

2.62e-09

GO:0022857

Transmembrane transporter activity

10 of 443

0.98

1.15

1.11e-07

GO:0015075

Ion transmembrane transporter activity

5 of 143

1.17

0.99

0.0013

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005886

Plasma membrane

10 of 900

0.68

0.61

2.76e-05

GO:0016021

Integral component of membrane

11 of 1053

0.65

0.6

9.82e-06

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:5386

Antiporter activity, and Proton-conducting membrane transporter

11 of 18

2.42

9.71

5.62e-23

CL:5409

Mixed, incl. Na+/H+ antiporter subunit, and Na+/H+ antiporter subunit E

5 of 5

2.63

4.61

1.53e-09

CL:5387

Proton-conducting membrane transporter, and Antiporter activity

4 of 10

2.23

2.77

3.25e-06

CL:5390

Mixed, incl. Na+/H+ antiporter subunit, and Na+/H+ antiporter subunit E

3 of 5

2.41

2.15

8.97e-05

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00190

Oxidative phosphorylation

4 of 63

1.43

1.18

0.0014

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0009521

Photosystem

2 of 5

2.23

0.82

0.0303

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-1133

Transmembrane helix

11 of 1017

0.66

0.61

1.06e-05

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF04066

Multiple resistance and pH regulation protein F (MrpF / PhaF)

2 of 2

2.63

0.94

0.0193

PF01899

Na+/H+ ion antiporter subunit

2 of 2

2.63

0.94

0.0193

PF00420

NADH-ubiquinone/plastoquinone oxidoreductase chain 4L

2 of 2

2.63

0.94

0.0193

PF00361

Proton-conducting membrane transporter

2 of 4

2.33

0.93

0.0193

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR039428

NADH-ubiquinone oxidoreductase chain 4L/Mnh complex subunit C1-like

2 of 2

2.63

0.72

0.0497

IPR007208

Na(+)/H(+) antiporter subunit F-like

2 of 2

2.63

0.72

0.0497

IPR002758

Na+/H+ antiporter subunit E

2 of 2

2.63

0.72

0.0497

IPR001750

NADH:quinone oxidoreductase/Mrp antiporter, membrane subunit

2 of 4

2.33

0.71

0.0497

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