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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
prpBMethylisocitrate lyase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family. (295 aa)    
Predicted Functional Partners:
SEB83464.1
Citrate synthase /2-methylcitrate synthase; Belongs to the citrate synthase family.
 
 0.987
prpD
2-methylcitrate dehydratase.
 
  
 0.957
gltA
Citrate synthase; Belongs to the citrate synthase family.
 
 0.954
SEB83515.1
Aconitase /2-methylcitrate dehydratase (trans-methylaconitate-forming).
 
 0.935
SEC90477.1
Aconitase; Belongs to the aconitase/IPM isomerase family.
    
 0.890
SEB83366.1
DNA-binding transcriptional regulator, GntR family.
 
  
 0.846
SEB83570.1
2-methylaconitate cis-trans isomerase.
 
  
 0.844
SEC92719.1
Fumarase, class I, homodimeric; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family.
 
  
 0.823
sucD
succinyl-CoA synthetase (ADP-forming) alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
    
 0.759
SEB83740.1
Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family.
   
 
 0.749
Your Current Organism:
Pseudomonas taetrolens
NCBI taxonomy Id: 47884
Other names: ATCC 4683, CCUG 560, CFBP 5592, CIP 103299, JCM 20238, LMG 2336, LMG:2336, NCIB 9396, NCIB:9396, NCTC 10697, NRRL B-14, NRRL B-731, NRRL:B:14, NRRL:B:731, P. taetrolens, VKM B-904, VKM:B:904
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