STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Sros_5922Uroporphyrinogen-III synthase-like protein; KEGG: scl:sce6449 putative transcriptional regulator. (389 aa)    
Predicted Functional Partners:
hemC
Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
  
 0.988
Sros_7364
KEGG: bpe:BP1055 siroheme synthase.
 
 
 0.978
Sros_0401
KEGG: pzu:PHZ_c2079 sensor histidine kinase/response regulator.
  
 
 0.960
Sros_1943
KEGG: afw:Anae109_0540 GAF sensor hybrid histidine kinase.
  
 
 0.960
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
 
 
 0.960
Sros_0550
KEGG: gme:Gmet_3235 uroporphyrinogen-III synthase / uroporphyrinogen-III C-methyltransferase.
 
 
 0.948
Sros_5921
Conserved hypothetical protein; KEGG: scl:sce0245 sirohydrochlorin cobaltochelatase.
 
  
 0.917
Sros_5924
KEGG: reu:Reut_B4860 assimilatory nitrite reductase (NAD(P)H) large subunit precursor; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.
 
  
 0.899
Sros_5923
KEGG: scl:sce8493 nitrite reductase (NAD(P)H).
 
  
 0.889
Sros_0551
Porphobilinogen synthase; KEGG: sfu:Sfum_3057 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family.
  
 
 0.862
Your Current Organism:
Streptosporangium roseum
NCBI taxonomy Id: 479432
Other names: S. roseum DSM 43021, Streptosporangium roseum DSM 43021, Streptosporangium roseum str. DSM 43021, Streptosporangium roseum strain DSM 43021
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