STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Caci_4501DNA-(apurinic or apyrimidinic site) lyase; PFAM: DNA glycosylase/AP lyase, H2TH DNA-binding; Formamidopyrimidine-DNA glycosylase catalytic domain protein; zinc finger Fpg domain protein; KEGG: sco:SCO0945 formamidopyrimidine-DNA glycosylase; Belongs to the FPG family. (288 aa)    
Predicted Functional Partners:
mutM
formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
  
  
0.934
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
  
 0.899
Caci_2443
PFAM: 5'-3' exonuclease; SMART: 5'-3' exonuclease; Helix-hairpin-helix domain protein class 2; KEGG: sgr:SGR_5889 putative 5'-3' exonuclease.
 
  
 0.680
Caci_3415
PFAM: DNA glycosylase/AP lyase, H2TH DNA-binding; Formamidopyrimidine-DNA glycosylase catalytic domain protein; KEGG: sma:SAV_2501 endonuclease VIII and DNA N- glycosylase with an AP lyase activity.
  
   
0.662
Caci_5866
PFAM: ATP dependent DNA ligase; ATP dependent DNA ligase domain protein; KEGG: sma:SAV_1697 ATP-dependent DNA ligase.
 
  
 0.641
coaE
dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family.
  
  
 0.632
Caci_5820
PFAM: ATP dependent DNA ligase; ATP dependent DNA ligase domain protein; KEGG: nfa:nfa25600 ATP-dependent DNA ligase.
 
  
 0.618
Caci_7074
TIGRFAM: HhH-GPD family protein; PFAM: HhH-GPD family protein; KEGG: sco:SCO4047 hypothetical protein.
  
  
 0.588
Caci_8366
PFAM: HhH-GPD family protein; helix-hairpin-helix motif; SMART: HhH-GPD family protein; iron-sulfur cluster loop; KEGG: sco:SCO3355 adenine glycosylase.
  
  
 0.580
Caci_1578
PFAM: DEAD/H associated domain protein; DEAD/DEAH box helicase domain protein; helicase domain protein; SMART: DEAD-like helicases; helicase domain protein; KEGG: sgr:SGR_1760 putative ATP-dependent DNA helicase.
  
  
 0.548
Your Current Organism:
Catenulispora acidiphila
NCBI taxonomy Id: 479433
Other names: C. acidiphila DSM 44928, Catenulispora acidiphila DSM 44928, Catenulispora acidiphila str. DSM 44928, Catenulispora acidiphila strain DSM 44928
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.