STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Sthe_1437Two component transcriptional regulator, winged helix family; PFAM: transcriptional regulator domain protein; response regulator receiver; SMART: response regulator receiver; KEGG: saq:Sare_0404 two component transcriptional regulator. (254 aa)    
Predicted Functional Partners:
Sthe_2665
Multi-sensor signal transduction histidine kinase; KEGG: scl:sce0186 two-component histidine kinase; TIGRFAM: PAS sensor protein; PFAM: ATP-binding region ATPase domain protein; GAF domain protein; PAS fold-4 domain protein; PAS fold domain protein; histidine kinase A domain protein; SMART: ATP-binding region ATPase domain protein; GAF domain protein; histidine kinase A domain protein; PAC repeat-containing protein.
 
 0.934
Sthe_3127
Two component transcriptional regulator, winged helix family; PFAM: transcriptional regulator domain protein; response regulator receiver; SMART: response regulator receiver; KEGG: hch:HCH_00579 response regulator.
  
  
 
0.900
Sthe_2401
Multi-sensor signal transduction histidine kinase; KEGG: ana:all5210 two-component hybrid sensor and regulator; TIGRFAM: PAS sensor protein; PFAM: ATP-binding region ATPase domain protein; PAS fold-4 domain protein; GAF domain protein; PAS fold domain protein; histidine kinase A domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein; GAF domain protein; PAS domain containing protein.
 
 
 0.899
Sthe_3274
Histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein; KEGG: glo:Glov_0589 multi-sensor signal transduction histidine kinase.
 
 0.870
Sthe_0750
Histidine kinase; KEGG: rrs:RoseRS_0613 integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein.
 
 0.868
Sthe_0911
Histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein; histidine kinase HAMP region domain protein; KEGG: hau:Haur_0906 integral membrane sensor signal transduction histidine kinase.
 
 0.852
Sthe_2198
Histidine kinase; KEGG: hau:Haur_0906 integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein; histidine kinase HAMP region domain protein.
 
 0.850
Sthe_2026
Histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; histidine kinase HAMP region domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein; histidine kinase HAMP region domain protein; KEGG: mta:Moth_1130 periplasmic sensor signal transduction histidine kinase.
   0.824
Sthe_3075
Multi-sensor signal transduction histidine kinase; KEGG: mxa:MXAN_7398 sensor histidine kinase; TIGRFAM: PAS sensor protein; PFAM: ATP-binding region ATPase domain protein; GAF domain protein; PAS fold-4 domain protein; PAS fold domain protein; histidine kinase A domain protein; SMART: ATP-binding region ATPase domain protein; GAF domain protein; histidine kinase A domain protein; PAS domain containing protein.
 
 
 0.812
Sthe_0181
Histidine kinase; KEGG: bcl:ABC0528 two-component sensor histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein; histidine kinase HAMP region domain protein.
   0.807
Your Current Organism:
Sphaerobacter thermophilus
NCBI taxonomy Id: 479434
Other names: S. thermophilus DSM 20745, Sphaerobacter thermophilus DSM 20745, Sphaerobacter thermophilus str. DSM 20745, Sphaerobacter thermophilus strain DSM 20745
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