STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Sthe_1467TIGRFAM: lipoprotein, YaeC family; PFAM: NLPA lipoprotein; KEGG: aoe:Clos_0544 NlpA lipoprotein. (304 aa)    
Predicted Functional Partners:
Sthe_1468
PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: esa:ESA_02819 hypothetical protein.
 0.999
metN
ABC transporter related protein; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system.
 0.999
Sthe_1543
KEGG: mta:Moth_1309 O-acetylhomoserine/O- acetylserine sulfhydrylase; TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism pyridoxal-phosphate- dependent protein; aromatic amino acid beta-eliminating lyase/threonine aldolase.
  
    0.789
metK
S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
  
  
 0.545
Sthe_2714
PFAM: methylenetetrahydrofolate reductase; KEGG: rlt:Rleg2_6552 methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.
  
  
 0.525
Sthe_2024
KEGG: sma:SAV_3510 cystathionine beta-synthase; TIGRFAM: cystathionine beta-synthase; cysteine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; CBS domain containing protein; SMART: CBS domain containing protein.
  
  
 0.483
Sthe_2815
PFAM: Methionine synthase vitamin-B12 independent; KEGG: vap:Vapar_1745 methionine synthase vitamin- B12 independent.
  
  
 0.459
Your Current Organism:
Sphaerobacter thermophilus
NCBI taxonomy Id: 479434
Other names: S. thermophilus DSM 20745, Sphaerobacter thermophilus DSM 20745, Sphaerobacter thermophilus str. DSM 20745, Sphaerobacter thermophilus strain DSM 20745
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