STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Sthe_2025PFAM: AMP-dependent synthetase and ligase; KEGG: pcl:Pcal_0155 AMP-dependent synthetase and ligase. (641 aa)    
Predicted Functional Partners:
Sthe_0650
KEGG: bld:BLi03062 methylcitrate synthase; TIGRFAM: 2-methylcitrate synthase/citrate synthase II; PFAM: Citrate synthase; Belongs to the citrate synthase family.
  
 0.961
Sthe_3481
KEGG: bba:Bd0562 hypothetical protein; TIGRFAM: 2-methylcitrate synthase/citrate synthase II; PFAM: Citrate synthase.
  
 0.961
Sthe_2906
Malate synthase A; KEGG: lhk:LHK_00649 AceB; TIGRFAM: malate synthase A; PFAM: Malate synthase family protein; Belongs to the malate synthase family.
   
 0.957
Sthe_0112
PFAM: Thiolase; KEGG: rci:RCIX150 acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.
  
 
 0.935
Sthe_2064
Citryl-CoA lyase; PFAM: HpcH/HpaI aldolase; KEGG: rxy:Rxyl_2830 citryl-CoA lyase; Belongs to the HpcH/HpaI aldolase family.
   
 0.932
Sthe_3523
PFAM: AMP-dependent synthetase and ligase; KEGG: dal:Dalk_0007 AMP-dependent synthetase and ligase.
  
  
 
0.922
Sthe_3226
PFAM: alpha/beta hydrolase fold; biotin/lipoyl attachment domain-containing protein; KEGG: pag:PLES_07751 branched-chain alpha-keto acid dehydrogenase subunit E2.
  
 
 0.920
leuA
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
  
 
 0.917
Sthe_0533
PFAM: CoA-binding domain protein; ATP-grasp domain protein; KEGG: bpy:Bphyt_4084 CoA-binding domain protein.
    
 0.914
Sthe_2381
PFAM: AMP-dependent synthetase and ligase; KEGG: sth:STH1025 acetyl-coenzyme A synthetase.
  
  
 
0.914
Your Current Organism:
Sphaerobacter thermophilus
NCBI taxonomy Id: 479434
Other names: S. thermophilus DSM 20745, Sphaerobacter thermophilus DSM 20745, Sphaerobacter thermophilus str. DSM 20745, Sphaerobacter thermophilus strain DSM 20745
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