STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Sthe_3316KEGG: scl:sce5225 protein kinase; TIGRFAM: diguanylate cyclase; PFAM: GGDEF domain containing protein; TPR repeat- containing protein; Tetratricopeptide TPR_4; Tetratricopeptide TPR_2 repeat protein; SMART: GGDEF domain containing protein; Tetratricopeptide repeat. (907 aa)    
Predicted Functional Partners:
Sthe_2695
Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s); KEGG: gsu:GSU2016 sensory box/GGDEF family protein; TIGRFAM: diguanylate cyclase; PAS sensor protein; PFAM: EAL domain protein; PAS fold-3 domain protein; GGDEF domain containing protein; PAS fold-4 domain protein; PAS fold domain protein; SMART: EAL domain protein; GGDEF domain containing protein; PAC repeat-containing protein; PAS domain containing protein.
 
 
0.922
Sthe_3170
KEGG: scl:sce6351 protein kinase; TIGRFAM: diguanylate cyclase; PFAM: GGDEF domain containing protein; tyrosine protein kinase; Serine/threonine protein kinase-related; GAF domain protein; SMART: GGDEF domain containing protein; serine/threonine protein kinase; tyrosine protein kinase; GAF domain protein.
 
  
0.786
Sthe_0710
Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s); KEGG: ana:all0219 hypothetical protein; TIGRFAM: diguanylate cyclase; PAS sensor protein; PFAM: EAL domain protein; PAS fold-3 domain protein; GGDEF domain containing protein; PAS fold domain protein; PAS fold-4 domain protein; SMART: EAL domain protein; GGDEF domain containing protein; PAS domain containing protein.
 
 
0.687
Sthe_3327
KEGG: scl:sce5225 protein kinase; TIGRFAM: diguanylate cyclase; PFAM: GGDEF domain containing protein; TPR repeat- containing protein; Tetratricopeptide TPR_4; Tetratricopeptide TPR_2 repeat protein; SMART: GGDEF domain containing protein; Tetratricopeptide repeat.
 
  
0.658
Sthe_1232
PFAM: Tetratricopeptide TPR_2 repeat protein; TPR repeat-containing protein; Tetratricopeptide TPR_4; KEGG: mag:amb4019 methyltransferase.
   
 
 0.616
Sthe_0595
Transcriptional regulator, LuxR family; PFAM: regulatory protein LuxR; regulatory protein MerR; SMART: regulatory protein LuxR; KEGG: sma:SAV_2729 LuxR family transcriptional regulator.
 
  
 0.579
Sthe_0598
Adenylate/guanylate cyclase with TPR repeats; PFAM: adenylyl cyclase class-3/4/guanylyl cyclase; Tetratricopeptide TPR_4; SMART: adenylyl cyclase class-3/4/guanylyl cyclase; Tetratricopeptide domain protein; KEGG: hau:Haur_1430 adenylate/guanylate cyclase.
 
  
 0.574
Sthe_0405
Diguanylate cyclase and metal dependent phosphohydrolase; KEGG: dau:Daud_0771 diguanylate cyclase with PAS/PAC sensor; TIGRFAM: diguanylate cyclase; PFAM: GGDEF domain containing protein; metal- dependent phosphohydrolase HD sub domain; GAF domain protein; Metal-dependent hydrolase HDOD; SMART: GGDEF domain containing protein; metal- dependent phosphohydrolase HD region; GAF domain protein.
 
 
0.570
Sthe_0966
KEGG: nth:Nther_2059 metal dependent phosphohydrolase; TIGRFAM: metal dependent phophohydrolase; PFAM: metal-dependent phosphohydrolase HD sub domain; SMART: metal-dependent phosphohydrolase HD region.
 
 
 0.562
Sthe_0072
Transcriptional regulator, XRE family; PFAM: helix-turn-helix domain protein; SMART: helix-turn-helix domain protein; Tetratricopeptide domain protein; KEGG: sus:Acid_5780 serine/threonine protein kinase.
 
  
 0.557
Your Current Organism:
Sphaerobacter thermophilus
NCBI taxonomy Id: 479434
Other names: S. thermophilus DSM 20745, Sphaerobacter thermophilus DSM 20745, Sphaerobacter thermophilus str. DSM 20745, Sphaerobacter thermophilus strain DSM 20745
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