STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Kfla_0157PFAM: Formamidopyrimidine-DNA glycosylase catalytic domain protein; DNA glycosylase/AP lyase, H2TH DNA- binding; KEGG: afw:Anae109_0505 DNA-formamidopyrimidine glycosylase; Belongs to the FPG family. (287 aa)    
Predicted Functional Partners:
mutM
formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
  
  
0.933
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
  
 0.873
Kfla_2997
DNA-(apurinic or apyrimidinic site) lyase; PFAM: Formamidopyrimidine-DNA glycosylase catalytic domain protein; DNA glycosylase/AP lyase, H2TH DNA- binding; KEGG: afw:Anae109_1725 DNA-(apurinic or apyrimidinic site) lyase; Belongs to the FPG family.
  
   
 0.829
Kfla_3608
PFAM: 5'-3' exonuclease; SMART: 5'-3' exonuclease; Helix-hairpin-helix domain protein class 2; KEGG: bba:Bd0802 DNA polymerase I.
 
  
 0.719
Kfla_0158
PFAM: Rhodanese domain protein; SMART: Rhodanese domain protein; KEGG: bch:Bcen2424_5472 beta-lactamase domain- containing protein.
       0.673
Kfla_3309
PFAM: ATP dependent DNA ligase; ATP dependent DNA ligase domain protein; KEGG: afw:Anae109_4038 ATP-dependent DNA ligase.
 
   
 0.666
Kfla_5843
TIGRFAM: HhH-GPD family protein; PFAM: HhH-GPD family protein.
  
  
 0.597
Kfla_2797
KEGG: tbd:Tbd_0827 DNA polymerase III, epsilon subunit; TIGRFAM: DNA polymerase III, epsilon subunit; PFAM: Exonuclease RNase T and DNA polymerase III; Excinuclease ABC C subunit domain protein; SMART: Exonuclease; Excinuclease ABC C subunit domain protein.
  
  
 0.596
coaE
dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family.
  
  
 0.586
Kfla_3428
TIGRFAM: HhH-GPD family protein; PFAM: HhH-GPD family protein.
  
  
 0.581
Your Current Organism:
Kribbella flavida
NCBI taxonomy Id: 479435
Other names: K. flavida DSM 17836, Kribbella flavida DSM 17836, Kribbella flavida str. DSM 17836, Kribbella flavida strain DSM 17836
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.