STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Kfla_0181methylated-DNA/protein- cysteinemethyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. (189 aa)    
Predicted Functional Partners:
Kfla_0182
RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: Sigma-70 region 4 type 2; sigma-70 region 2 domain protein; KEGG: ret:RHE_PC00138 RNA polymerase sigma-E factor; Belongs to the sigma-70 factor family. ECF subfamily.
 
     0.860
Kfla_5855
Transcriptional regulator, AraC family; PFAM: Ada metal-binding domain protein; AlkA domain protein; HhH-GPD family protein; helix-turn-helix- domain containing protein AraC type; SMART: HhH-GPD family protein; helix-turn-helix- domain containing protein AraC type; KEGG: scl:sce6205 putative regulatory protein Ada.
  
  
 0.683
Kfla_5872
Deoxyribodipyrimidine photo-lyase; PFAM: DNA photolyase FAD-binding; DNA photolyase domain protein; KEGG: pla:Plav_0513 deoxyribodipyrimidine photo- lyase.
     
 0.666
Kfla_1871
Transcriptional regulator, AraC family; PFAM: AlkA domain protein; Ada metal-binding domain protein; helix-turn-helix- domain containing protein AraC type; SMART: helix-turn-helix- domain containing protein AraC type; KEGG: scl:sce6205 putative regulatory protein Ada.
  
  
 0.635
Kfla_0183
Hypothetical protein.
       0.553
Kfla_6428
PFAM: HhH-GPD family protein; helix-hairpin-helix motif; SMART: HhH-GPD family protein; iron-sulfur cluster loop; KEGG: msl:Msil_1600 A/G-specific adenine glycosylase.
 
   
 0.483
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
 
 
 
 0.425
Kfla_3427
PFAM: UspA domain protein; KEGG: rfr:Rfer_0629 hypothetical protein.
  
    0.419
Kfla_3652
PFAM: UspA domain protein; KEGG: dia:Dtpsy_2423 UspA domain protein.
  
    0.419
pheT
TIGRFAM: phenylalanyl-tRNA synthetase, beta subunit; KEGG: afw:Anae109_1884 phenylalanyl-tRNA synthetase, beta subunit.
     
 0.401
Your Current Organism:
Kribbella flavida
NCBI taxonomy Id: 479435
Other names: K. flavida DSM 17836, Kribbella flavida DSM 17836, Kribbella flavida str. DSM 17836, Kribbella flavida strain DSM 17836
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.