STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Kfla_0905KEGG: mfa:Mfla_0558 DNA topoisomerase, type I, putative. (337 aa)    
Predicted Functional Partners:
Kfla_5337
PFAM: UvrD/REP helicase; HRDC domain protein; SMART: HRDC domain protein; KEGG: gsu:GSU3411 ATP-dependent DNA helicase PcrA, putative.
    
 
 0.812
gyrB
DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
   
 
 0.774
Kfla_3443
KEGG: DNA topoisomerase, ATP-hydrolyzing, putative.
   
 
 0.774
Kfla_5664
PFAM: GCN5-related N-acetyltransferase; KEGG: psa:PST_0004 DNA gyrase subunit B.
   
 
 0.774
rnhB
Ribonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
    
 
 0.713
ku
Ku protein; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family.
 
    0.650
Kfla_0694
TIGRFAM: DNA ligase D, 3'-phosphoesterase domain protein; KEGG: pmy:Pmen_3217 ATP-dependent DNA ligase.
 
 
 
 0.617
Kfla_0906
KEGG: pzu:PHZ_c1924 hypothetical protein.
 
     0.600
Kfla_1928
PFAM: short-chain dehydrogenase/reductase SDR; KR domain protein; KEGG: xac:XAC1178 oxidoreductase.
  
 
   0.563
Kfla_0904
PFAM: CsbD family protein; KEGG: pfo:Pfl01_4351 CsbD-like; Belongs to the UPF0337 (CsbD) family.
       0.558
Your Current Organism:
Kribbella flavida
NCBI taxonomy Id: 479435
Other names: K. flavida DSM 17836, Kribbella flavida DSM 17836, Kribbella flavida str. DSM 17836, Kribbella flavida strain DSM 17836
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