STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PHMEG_0008251DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1539 aa)    
Predicted Functional Partners:
PHMEG_00011301
DNA topoisomerase.
   
 
 0.876
PHMEG_00022093
Small ubiquitinlike modifier (SUMO) protein.
    
 0.861
PHMEG_0008856
Condensin complex subunit 2.
   
 
 0.825
PHMEG_00010094
Structural maintenance of chromosomes protein.
   
 
 0.821
PHMEG_00010925
SUMO ligase.
    
 0.813
PHMEG_0004854
Structural maintenance of chromosomes protein.
   
 
 0.798
PHMEG_00022933
SUMO-conjugating enzyme (SCE); Belongs to the ubiquitin-conjugating enzyme family.
   
 0.747
PHMEG_00040004
Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.
  
 
 0.742
PHMEG_0006520
Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family.
  
  
 0.721
PHMEG_00012035
Uncharacterized protein.
   
 
 0.710
Your Current Organism:
Phytophthora megakarya
NCBI taxonomy Id: 4795
Other names: ATCC 42100, CBS 238.83, IMI 202077, P. megakarya
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.