STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
Cooccurrence
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[Homology]
Score
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (331 aa)    
Predicted Functional Partners:
AKJ00255.1
Acetolactate synthase large subunit; Belongs to the TPP enzyme family.
 
 0.991
AKJ05122.1
Acetolactate synthase large subunit; Belongs to the TPP enzyme family.
 
 
 0.989
AKJ05189.1
Acetolactate synthase large subunit; Belongs to the TPP enzyme family.
 
 0.983
AKJ07293.1
Isocitrate dehydrogenase.
 
  
 0.921
AKJ03741.1
Hydroxymethylglutaryl-CoA lyase.
  
  
 0.894
AKJ07258.1
Glutamate synthase [NADPH] large chain.
 
  
 0.790
AKJ02509.1
Pyruvate oxidase; Belongs to the TPP enzyme family.
 
  
 0.787
AKI99388.1
Ortho-halobenzoate 1,2-dioxygenase alpha-ISP protein OhbB.
       0.727
AKI99389.1
Ortho-halobenzoate 1,2-dioxygenase beta-ISP protein OhbA.
       0.727
AKJ07377.1
Threonine synthase.
 
  
 0.716
Your Current Organism:
Archangium gephyra
NCBI taxonomy Id: 48
Other names: A. gephyra, ATCC 25201, Chondrococcus cerebriformis, Chondromyces serpens, DSM 2261, Myxococcus cerebriformis
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