node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AKJ02521.1 | glyA | AA314_04147 | AA314_04148 | Ribose 5-phosphate isomerase B. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.981 |
AKJ05373.1 | AKJ07300.1 | AA314_06999 | AA314_08926 | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Folate-dependent protein; Belongs to the GcvT family. | 0.404 |
AKJ05373.1 | gcvH | AA314_06999 | AA314_06616 | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.454 |
AKJ05373.1 | gcvP | AA314_06999 | AA314_06614 | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.694 |
AKJ05373.1 | gcvT | AA314_06999 | AA314_06617 | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.404 |
AKJ05373.1 | glyA | AA314_06999 | AA314_04148 | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.962 |
AKJ07300.1 | AKJ05373.1 | AA314_08926 | AA314_06999 | Folate-dependent protein; Belongs to the GcvT family. | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.404 |
AKJ07300.1 | folD | AA314_08926 | AA314_04126 | Folate-dependent protein; Belongs to the GcvT family. | Methylenetetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.953 |
AKJ07300.1 | folD-2 | AA314_08926 | AA314_06624 | Folate-dependent protein; Belongs to the GcvT family. | Methylenetetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.953 |
AKJ07300.1 | gcvH | AA314_08926 | AA314_06616 | Folate-dependent protein; Belongs to the GcvT family. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.999 |
AKJ07300.1 | gcvP | AA314_08926 | AA314_06614 | Folate-dependent protein; Belongs to the GcvT family. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.999 |
AKJ07300.1 | gcvT | AA314_08926 | AA314_06617 | Folate-dependent protein; Belongs to the GcvT family. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.927 |
AKJ07300.1 | glyA | AA314_08926 | AA314_04148 | Folate-dependent protein; Belongs to the GcvT family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.966 |
AKJ07300.1 | purH | AA314_08926 | AA314_06773 | Folate-dependent protein; Belongs to the GcvT family. | IMP cyclohydrolase. | 0.936 |
AKJ07300.1 | purN | AA314_08926 | AA314_06955 | Folate-dependent protein; Belongs to the GcvT family. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.934 |
folD | AKJ07300.1 | AA314_04126 | AA314_08926 | Methylenetetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Folate-dependent protein; Belongs to the GcvT family. | 0.953 |
folD | folD-2 | AA314_04126 | AA314_06624 | Methylenetetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Methylenetetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.905 |
folD | gcvH | AA314_04126 | AA314_06616 | Methylenetetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.724 |
folD | gcvP | AA314_04126 | AA314_06614 | Methylenetetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.846 |
folD | gcvT | AA314_04126 | AA314_06617 | Methylenetetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.953 |